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	Provedor de dados BJMBR (1) Autor Aguilar-Carrasco,J.C. (1) Castillo-Henkel,E.F. (1) Lozano-Cuenca,J. (1) López-Canales,J.S. (1) López-Canales,O.A. (1) López-Mayorga,R.M. (1) Villagrana-Zesati,J.R. (1) Mais... Palavra-chave K+ channels (1) NO-cGMP/PKG pathway (1) Rat aorta (1) Triiodothyronine (1) Vasorelaxation (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2016 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Pharmacological study of the mechanisms involved in the vasodilator effect produced by the acute application of triiodothyronine to rat aortic rings BJMBR Lozano-Cuenca,J.; López-Canales,O.A.; Aguilar-Carrasco,J.C.; Villagrana-Zesati,J.R.; López-Mayorga,R.M.; Castillo-Henkel,E.F.; López-Canales,J.S.. A relationship between thyroid hormones and the cardiovascular system has been well established in the literature. The present in vitro study aimed to investigate the mechanisms involved in the vasodilator effect produced by the acute application of 10-8–10-4 M triiodothyronine (T3) to isolated rat aortic rings. Thoracic aortic rings from 80 adult male Wistar rats were isolated and mounted in tissue chambers filled with Krebs-Henseleit bicarbonate buffer in order to analyze the influence of endothelial tissue, inhibitors and blockers on the vascular effect produced by T3. T3 induced a vasorelaxant response in phenylephrine-precontracted rat aortic rings at higher concentrations (10-4.5–10-4.0 M). This outcome was unaffected by 3.1×10-7 M glibenclamide,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Triiodothyronine; Rat aorta; Vasorelaxation; NO-cGMP/PKG pathway; K+ channels. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000800604 Registros recuperados: 1 Primeira ... 1 ... Última

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