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Registros recuperados: 29 | |
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TORRES,Maycon de Paula Ribeiro; ESPRENDOR,Rhuan Vínicius de Freitas; BONALDO,Solange Maria; RIBEIRO,Elton Brito; VALLADÃO,Dênia Mendes de Sousa. |
ABSTRACT Advances in nanotechnology, combined with the use of natural products, represent a promissing research field. Brazil is a country of a rich biodiversity, especially in the Amazon forest. Fruits commonly used by local communities, such as bacaba (Oenocarpus bacaba), are potentially important for prospection of industrial applications of natural products. In nanotechnology, microemulsions stand out for providing a modified release to conveyed substances. This work aimed to develop microemulsionated formulations of bacaba oil, characterize them and evaluate their stability. We determined the HLB (hydrophile-lipophilic balance) of bacaba oil for formulation development. Six formulations were selected from pseudoternary diagrams, which indicated the... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Microemulsion; Amazon; Native fruit; Nanotechnology; Carriers. |
Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672019000300246 |
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BORIN,DIEGO B.; MEZZOMO,NATHANA J.; VAUCHER,RODRIGO A.; CARMO,GUILHERME DO; RODRIGUES JUNIOR,LUIZ C.; SULCZEWSKI,FERNANDO B.; SCHWERTZ,CLAITON I.; MENDES,RICARDO E.; DAMIANI,ADRIANI P.; ANDRADE,VANESSA M. DE; RECH,VIRGÍNIA C.; BOECK,CARINA R.. |
ABSTRACT Creatine acts intracellularly as energy buffer and storage, demonstrating protective effects in animal models of neurodegenerative diseases. However, its permeability throught blood-brain barrier (BBB) is reduced. The aim of the present study was developing a carrier to facilitate the delivery of creatine to the central nervous system. Creatine nanoliposomes were produced, characterized and assayed in models of toxicity in vitro and in vivo. Particles showed negative zeta potential (-12,5 mV), polydispersity index 0.237 and medium-size of 105 nm, which was confirmed by transmission electron microscopy (TEM) images. Toxicity assay in vitro was evaluated with blank liposomes (no drug) or creatine nanoliposomes at concentrations of 0.02 and 0.2... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nanocarrier; Neurodegenerative diseases; Nanotechnology; Liposomes. |
Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000502317 |
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SOUZA,CARINE F.; LIMA,TÁBATA; BALDISSERA,MATHEUS D.; GEIHS,MÁRCIO A.; MACIEL,FÁBIO E.; NERY,LUIZ E.M.; SANTOS,ROBERTO C.V.; RAFFIN,RENATA P.; HEINZMANN,BERTA M.; CARON,BRAULIO O.; BALDISSEROTTO,BERNARDO. |
ABSTRACT The aim of this study was to evaluate the efficacy and safety of several anesthetics in the brachyuran crab Neohelice granulata, an emergent experimental model. The essential oils (EOs) of Lippia alba, Aloysia tryphilla, and Melaleuca alternifolia (tea tree oil; TTO), the isolated compounds eugenol, menthol, terpinen-4-ol, and the nanoencapsulated form of TTO, were administered in one or more of the following ways: added to the water (immersion), through an arthrodial membrane (injected), or by oral gavage. Unexpectedly, most EOs did not produce an anesthetic effect after immersion. Only TTO and eugenol induced anesthesia by immersion, with very long induction and recovery times compared to anesthesia of other crustaceans. However, a good... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Anesthesia; Eugenol; Terpinen-4-ol; Nanotechnology; Invertebrate; Tea-tree-oil. |
Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000602855 |
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Vulcani,V.A.S.; Franzo,V.S.; Rabelo,R.E.; Rabbers,A.S.; Assis,B.M.; D'Ávila,M.A.; Antoni,S.M.B.. |
Electrospinning is a technique that allows the preparation of nanofibers from various materials. Chitosan is a natural and abundant easily obtained polymer, which, in addition to those features, proved to be biocompatible. This work used nanostructured chitosan and polyoxyethylene membranes as subcutaneous implants in Wistar rats to evaluate the biocompatibility of the material. Samples of the material and tissues adjacent to the implant were collected 7, 15, 30, 45 and 60 days post-implantation. Macroscopic integration of the material to the tissues was observed in the samples and slides for histopathological examination that were prepared. It was noticed that the material does not stimulate the formation of adherences to the surrounding tissues and that... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nanotechnology; Biomaterials; Electrospinning. |
Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352015000401039 |
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Alves,Andrea Catão; Gontijo,Cristiano Machado; Oliveira,Mônica Cristina; Diniz,Simone Odília Fernandes; Oliveira,Flávia Márcia; Cardoso,Valbert Nascimento; Ramaldes,Gilson Andrade. |
The oral administration of proteic antigens, like ovalbumin, may result in the induction of oral tolerance or immunization. The aim of this work was to label a protein antigen with 99mTechnetium, encapsulate it in liposomes and investigate its absorption and tissue distribution after oral administration in mice. Ovalbumin was labeled with 99mTechnetium and encapsulated in small unilamellar vesicles. 99mTc-OVA encapsulated or not in liposomes was administrated to mice that were sacrificed after different times. The radioactivity was measured in various organs of the animals. Differences concerning the biodistribution of 99mTc-OVA were noticed. The technique may represent alternatives for the induction of immunization or oral tolerance. |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Liposomes; Oral absorption; Mucosal delivery; Proteins; Nanotechnology. |
Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700035 |
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Joviano-Santos,J.V.; Sá,M.A.; De Maria,M.L.A.; Almeida,T.C.S.; Geraldo,V.; Oliveira,S.; Ladeira,L.O.; Ferreira,A.J.. |
It has been demonstrated that carbon nanotubes (CNTs) associated with sodium hyaluronate (HY-CNTs) accelerate bone repair in the tooth sockets of rats. Before clinical application of HY-CNTs, it is important to assess their biocompatibility. Moreover, cardiac toxicity may be caused by the translocation of these particles to the blood stream. The aim of this study was to evaluate possible changes in cardiovascular function in male Wistar rats whose tooth sockets were treated with either CNTs or HY-CNTs (100 μg/mL, 0.1 mL). Blood pressure and heart rate were monitored in conscious rats 7 days after treatment. Cardiac function was evaluated using the Langendorff perfusion technique. The data showed no changes in blood pressure or heart rate in rats treated... |
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Palavras-chave: Cardiac function; Blood pressure; Carbon nanotubes; Nanotechnology; Bone repair; Tooth sockets. |
Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000700560 |
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Sá,M.A.; Ribeiro,H.J.; Valverde,T.M.; Sousa,B.R.; Martins-Júnior,P.A.; Mendes,R.M.; Ladeira,L.O.; Resende,R.R.; Kitten,G.T.; Ferreira,A.J.. |
The aim of this study was to evaluate the effects of sodium hyaluronate (HY), single-walled carbon nanotubes (SWCNTs) and HY-functionalized SWCNTs (HY-SWCNTs) on the behavior of primary osteoblasts, as well as to investigate the deposition of inorganic crystals on titanium surfaces coated with these biocomposites. Primary osteoblasts were obtained from the calvarial bones of male newborn Wistar rats (5 rats for each cell extraction). We assessed cell viability using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay and by double-staining with propidium iodide and Hoechst. We also assessed the formation of mineralized bone nodules by von Kossa staining, the mRNA expression of bone repair proteins, and the deposition of inorganic... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Osteoblast; Nanotechnology; Carbon nanotubes; Sodium hyaluronate; Tissue engineering; Osseointegration. |
Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000200602 |
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Yurgel,V.; Collares,T.; Seixas,F.. |
The application of nanotechnology to medicine can provide important benefits, especially in oncology, a fact that has resulted in the emergence of a new field called Nanooncology. Nanoparticles can be engineered to incorporate a wide variety of chemotherapeutic or diagnostic agents. A nanocapsule is a vesicular system that exhibits a typical core-shell structure in which active molecules are confined to a reservoir or within a cavity that is surrounded by a polymer membrane or coating. Delivery systems based on nanocapsules are usually transported to a targeted tumor site and then release their contents upon change in environmental conditions. An effective delivery of the therapeutic agent to the tumor site and to the infiltrating tumor cells is difficult... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nanotechnology; Nanocapsules; Nanocarriers; Cancer. |
Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000600486 |
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Carneiro,Jaqueline; Döll-Boscardin,Patrícia Mathias; Fiorin,Bárbara Celânia; Nadal,Jessica Mendes; Farago,Paulo Vitor; Paula,Josiane Padilha de. |
ABSTRACT Skin aging causes changes such as wrinkles and flaccidity leading to a large demand for aesthetic procedures, including dermal filling. A key agent in dermal filling is hyaluronic acid (HA), which is a naturally occurring glycosaminoglycan. However, it is a hydrophilic macromolecule that experiences great difficulty in crossing the skin barrier causing most commercial formulations containing it to be injectable, which in turn brings risks since they involve an invasive technique. In that sense, the aim of this study was to develop and characterize nanoparticles obtained from ionic interaction between HA and lysine (Lys) for use as a potential agent of dermal filling for topical application, increasing and improving its applicability and safety. To... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nanotechnology; Skin aging/non-invasive method; Skin aging/treatment/study.. |
Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400645 |
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Schnettler,Berta; Crisóstomo,Gloria; Mills,Natally; Miranda,Horacio; Mora,Marcos; Lobos,Germán; Grunert,Klaus G. |
In light of the increasing use of nanotechnology in food production, consumer acceptance of sunflower oil produced with nanotechnology or from genetically modified (GM) plants and the conventionally produced raw materials available in Temuco (Araucanía Region, Chile), market segments were differentiated with respect to their acceptance of nanotechnology and characterized according to their sociodemographic characteristics and food neophobia level. To achieve this aim, a survey was administered to 400 people. Using a conjoint analysis, the brand (33.6%) and production system (32.6%) were determined to be more important than the price (19.2%) and health certification (14.6%); national brands, produced conventionally with a health certification seal and sold... |
Tipo: Journal article |
Palavras-chave: Sunflower oil; Transgenic food; Nanotechnology. |
Ano: 2013 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-16202013000100002 |
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Ramírez Mella, Mónica. |
La presente tesis se compone de la Introducción General, Revisión de literatura, tres capítulos que engloban la investigación, objeto de este estudio, y Conclusiones y Recomendaciones Generales. El Capítulo 1 consiste en un artículo de revisión de literatura que enmarca la importancia de proteger ingredientes y/o compuestos del ataque de microrganismos a nivel ruminal, donde la nanotecnología ocupa un papel importante. En el Capítulo 2 se discute el efecto de la vitamina E en la composición de la leche de vacas en pastoreo que recibieron un suplemento de ácido linoleico conjugado microencapsulado, así como un análisis económico del mismo. El Capítulo 3 consiste en el estudio del efecto de la vitamina E en la fermentación ruminal y la digestión de... |
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Palavras-chave: Nanotecnología; Microencapsulación; CLA; Grasa en leche; Vacas en pastoreo; Nanotechnology; Microencapsulation; Fat milk; Grazing dairy cows; Ganadería; Doctorado. |
Ano: 2012 |
URL: http://hdl.handle.net/10521/1743 |
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Registros recuperados: 29 | |
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