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Msxb is a core component of the genetic circuitry specifying the dorsal and ventral neurogenic midlines in the ascidian embryo ArchiMer
Roure, Agnes; Darras, Sebastien.
The tail ascidian larval peripheral nervous system is made up of epidermal sensory neurons distributed more or less regularly in ventral and dorsal midlines. Their formation occurs in two-steps: the ventral and dorsal midlines are induced as neurogenic territories by Fgf9/-16/20 and Admp respectively. The Delta2/Notch interaction,then controls the number of neurons that form. The genetic machinery acting between the inductive processes taking place before gastrulation and neuron specification at tailbud stages are largely unknown. The analysis of seven transcription factors expressed in the forming midlines revealed an unexpected complexity and dynamic of gene expression. Their systematic overexpression confirmed that these genes do not interact following...
Tipo: Text Palavras-chave: Ascidian; Gene regulatory network; Transcription factors; Peripheral nervous system; Neurogenic.
Ano: 2016 URL: https://archimer.ifremer.fr/doc/00374/48557/48984.pdf
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