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	Provedor de dados 56 (2) Autor Alves,A.S. (1) Britto,L.R.G. (1) Chacur,M. (1) Cury,Y. (1) Deakin,J.F.W. (1) Guimarães,F.S. (1) Gutierrez,V. (1) Matos,R.J.B. (1) Oliveira,R.M.W. (1) Rodrigues,A.C. (1) Mais... Palavra-chave Neuronal nitric oxide synthase (2) Affective disorders (1) Allodynia (1) Hippocampus (1) Immunohistochemistry (1) Major depression (1) Neuropathic pain (1) Peripheral neuropathy (1) Sciatic nerve transection (1) Spinal cord (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2010 (1) 2008 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Expression of neuronal nitric oxide synthase in the hippocampal formation in affective disorders 56 Oliveira,R.M.W.; Guimarães,F.S.; Deakin,J.F.W.. Hippocampal output is increased in affective disorders and is mediated by increased glutamatergic input via N-methyl-D-aspartate (NMDA) receptor and moderated by antidepressant treatment. Activation of NMDA receptors by glutamate evokes the release of nitric oxide (NO) by the activation of neuronal nitric oxide synthase (nNOS). The human hippocampus contains a high density of NMDA receptors and nNOS-expressing neurons suggesting the existence of an NMDA-NO transduction pathway which can be involved in the pathogenesis of affective disorders. We tested the hypothesis that nNOS expression is increased in the human hippocampus from affectively ill patients. Immunocytochemistry was used to demonstrate nNOS-expressing neurons in sections obtained from the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Affective disorders; Major depression; Neuronal nitric oxide synthase; Immunohistochemistry; Hippocampus. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000400012 Participation of neuronal nitric oxide synthase in experimental neuropathic pain induced by sciatic nerve transection 56 Chacur,M.; Matos,R.J.B.; Alves,A.S.; Rodrigues,A.C.; Gutierrez,V.; Cury,Y.; Britto,L.R.G.. Nerve injury leads to a neuropathic pain state that results from central sensitization. This phenomenom is mediated by NMDA receptors and may involve the production of nitric oxide (NO). In this study, we investigated the expression of the neuronal isoform of NO synthase (nNOS) in the spinal cord of 3-month-old male, Wistar rats after sciatic nerve transection (SNT). Our attention was focused on the dorsal part of L3-L5 segments receiving sensory inputs from the sciatic nerve. SNT resulted in the development of neuropathic pain symptoms confirmed by evaluating mechanical hyperalgesia (Randall and Selitto test) and allodynia (von Frey hair test). Control animals did not present any alteration (sham-animals). The selective inhibitor of nNOS, 7-nitroindazole... Tipo: Info:eu-repo/semantics/article Palavras-chave: Allodynia; Neuropathic pain; Neuronal nitric oxide synthase; Peripheral neuropathy; Sciatic nerve transection; Spinal cord. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000400008 Registros recuperados: 2 Primeira ... 1 ... Última

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