|
|
| SAKURABA,SHIGEKI; KUWANA,SHUN-ICHI; ERIKSSON,LARS I; OKADA,YASUMASA; OCHIAI,RYOICHI; KASHIWAGI,MASANORI; HATORI,EIKI; LINDAHL,STEN G. E.; TAKEDA,JUNZO. |
| Neuromuscular blocking agents suppress central respiratory activity through their inhibitory effects on preinspiratory neurons and the synaptic drive from preinspiratory neurons to inspiratory neurons. Central CO2-chemosensitive areas, which partly consist of CO2-excited neurons, in the rostral ventrolateral medulla are thought to provide tonic drive to the central respiratory network and involve cholinergic mechanisms, which led us to hypothesize that neuromuscular blocking agents can inhibit CO2-excited neurons and attenuate respiratory CO2 responsiveness. To test this hypothesis, we used isolated brainstem-spinal cord preparations from newborn rats. The increase of C4 burst frequency induced by a hypercapnic superfusate, i.e. respiratory CO2... |
| Tipo: Journal article |
Palavras-chave: Brainstem; Chemosensitivity; CO2 responsiveness; Muscle relaxant; Nicotinic acetylcholine. |
| Ano: 2005 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200012 |
| |
