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The Hardy-Weinberg principle Genet. Mol. Biol.
Stark,Alan E..
Hardy-Weinberg genotypic proportions can be maintained in a population under non-random mating. A compact formula gives the proportions of mating pair types. These are illustrated by some simple examples.
Tipo: Info:eu-repo/semantics/other Palavras-chave: Hardy-Weinberg equilibrium; Non-random mating.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000300027
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On extending the Hardy-Weinberg law Genet. Mol. Biol.
Stark,Alan E..
This paper gives a general mating system for an autosomal locus with two alleles. The population reproduces in discrete and non-overlapping generations. The parental population, the same in both sexes, is arbitrary as is that of the offspring and the gene frequencies of the parents are maintained in the offspring. The system encompasses a number of special cases including the random mating model of Weinberg and Hardy. Thus it demonstrates, in the most general way possible, how genetic variation can be conserved in an indefinitely large population without invoking random mating or balancing selection. An important feature is that it provides a mating system which identifies when mating does and does not produce Hardy-Weinberg proportions among offspring.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hardy-Weinberg law; Non-random mating; General offspring distribution.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000400026
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Stages in the evolution of the Hardy-Weinberg law Genet. Mol. Biol.
Stark,Alan E..
The Hardy-Weinberg law has been used widely for about one hundred years with little question as to the foundations laid down by its originators. The basic assumption of random mating, that is choice of mates by a process akin to that of a lottery, was shown to produce genotypic proportions following the "binomial-square" rule, the so-called Hardy-Weinberg proportions (HWP). It has been assumed by many that random mating was the only way of pairing genes capable of producing HWP. However it has been shown that HWP can be obtained and maintained by non-random mating. The steps along the way to this revelation and some implications are reviewed.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hardy-Weinberg law; Non-random mating.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000400001
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