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| LEAL,DALILA T.; FONTES,GLEIDE G.; VILLA,JULIA K.D.; FREITAS,RODRIGO B.; CAMPOS,MATEUS G.; CARVALHO,CAMILO A.; PIZZIOLO,VIRGINIA R.; DIAZ,MARISA A.N.. |
| Abstract: This study investigated the ability of formulation containing Zingiber officinale (ginger) to reverse health changes promoted by unhealthy diet in Wistar rats. Five compounds from the gingerol family and three from the shogaol family were identified in the chromatographic analyzes of the extract. The animals were fed a combination of unhealthy foods, the cafeteria diet, which promoted increases in body weight, hepatocyte nucleus area, total hepatocyte area and liver fat accumulation, as well as reduced hepatic glutathione S-transferase concentration, compared to the control group, which received commercial chow. The treatment with ginger improved all these results, highlighting the reduction of 10% of body weight and 66% of the total area of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cafeteria diet; Gingerol; Nonalcoholic fatty liver disease; Oxidative stress; Shogaol; Zingiber officinale. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000700801 |
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| Santos,V.N.; Lanzoni,V.P.; Szejnfeld,J.; Shigueoka,D.; Parise,E.R.. |
| In order to determine the effect of ursodeoxycholic acid on nonalcoholic fatty liver disease, 30 patients with body mass indices higher than 25, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) or gamma-glutamyltransferase (gamma-GT) at least more than 1.5 times the upper limit of normality, and hepatic steatosis demonstrated by ultrasonography were randomized into two groups of 15 patients to receive placebo or 10 mg kg-1 day-1 ursodeoxycholic acid for three months. Abdominal computed tomography was performed to quantify hepatic fat content, which was significantly correlated with histological grading of steatosis (r s = -0.83, P < 0.01). Patient body mass index remained stable for both groups throughout the study, but a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Fatty liver; Ursodeoxycholic acid. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000600007 |
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| Zhang,W.-J.; Chen,L.-L.; Zheng,J.; Lin,L.; Zhang,J.-Y.; Hu,X.. |
| Our objective was to examine associations of adult weight gain and nonalcoholic fatty liver disease (NAFLD). Cross-sectional interview data from 844 residents in Wan Song Community from October 2009 to April 2010 were analyzed in multivariate logistic regression models to examine odds ratios (OR) and 95% confidence intervals (CI) between NAFLD and weight change from age 20. Questionnaires, physical examinations, laboratory examinations, and ultrasonographic examination of the liver were carried out. Maximum rate of weight gain, body mass index, waist circumference, waist-to-hip ratio, systolic blood pressure, diastolic blood pressure, fasting blood glucose, cholesterol, triglycerides, uric acid, and alanine transaminase were higher in the NAFLD group than... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: China; Diabetes; Insulin resistance; Lipidosis; Nonalcoholic fatty liver disease; Obesity. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000200151 |
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| Oliveira,C.P.M.S.; Coelho,A.M.M.; Barbeiro,H.V.; Lima,V.M.R.; Soriano,F.; Ribeiro,C.; Molan,N.A.T.; Alves,V.A.F.; Souza,H.P.; Machado,M.C.C.; Carrilho,F.J.. |
| Oxidative stress and hepatic mitochondria play a role in the pathogenesis of nonalcoholic fatty liver disease. The aim of the present study was to evaluate the role of hepatic mitochondrial dysfunction and oxidative stress in the pathogenesis of the disease. Fatty liver was induced in Wistar rats with a choline-deficient diet (CD; N = 7) or a high-fat diet enriched with PUFAs-omega-3 (H; N = 7) for 4 weeks. The control group (N = 7) was fed a standard diet. Liver mitochondrial oxidation and phosphorylation were measured polarographically and oxidative stress was estimated on the basis of malondialdehyde and glutathione concentrations. Moderate macrovacuolar liver steatosis was observed in the CD group and mild liver steatosis was observed in the periportal... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatic mitochondrial dysfunction; Oxidative stress; Nonalcoholic fatty liver disease; Choline-deficient diet; High-fat diet. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000200004 |
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