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	Provedor de dados BABT (1) BJPS (1) Autor Azizi,Vahid (1) Ghazvini,Hamed (1) Hewedy,Wafaa Ahmed (1) Khalifeh,Solmaz (1) Khodagholi,Fariba (1) Shaerzadeh,Fatemeh (1) Zarrindast,Mohammad-Reza (1) Mais... Palavra-chave Nrf2 (2) Acetaminophen (1) Antioxidant defense system (1) Citrate synthase (1) Dipeptidyl peptidase-4 inhibitors (1) Hepatotoxicity (1) Malate dehydrogenase (1) PGC1-α (1) Sitagliptin (1) TFAM (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2020 (1) 2017 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Brain Region Specificity of Mitochondrial Biogenesis and Bioenergetics Response to Nrf2 Knockdown: A Comparison Among Hippocampus, Prefrontal Cortex and Amygdala of Male Rat Brain BABT Khalifeh,Solmaz; Khodagholi,Fariba; Shaerzadeh,Fatemeh; Ghazvini,Hamed; Zarrindast,Mohammad-Reza; Azizi,Vahid. ABSTRACT Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) has been identified as the well-known coordinator of intracellular antioxidant defense system. Herein, we aimed to evaluate the effects of Nrf2 silencing on mitochondrial biogenesis markers peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), nuclear respiratory factor-1(NRF-1), mitochondrial transcription factor A (TFAM) and cytochrome c as well activities of two enzymes citrate synthase (CS) and malate dehydrogenase (MDH) in three brain regions hippocampus, amygdala, and prefrontal cortex of male Wistar rats. Small interfering RNA (siRNA) targeting Nrf2 was injected in dorsal third ventricle. Next, western blot analysis and biochemical assays were used to evaluation of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nrf2; Antioxidant defense system; Citrate synthase; Malate dehydrogenase; PGC1-α; TFAM. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100428 Effects of treatment with sitagliptin on hepatotoxicity induced by acetaminophen in mice BJPS Hewedy,Wafaa Ahmed. Up to date, the management of hepatotoxicity induced by a suicidal or unintentional overdose of acetaminophen (APAP) remains a therapeutic challenge. The present study aimed to elucidate the potential effect of sitagliptin, a DPP-4 inhibitor, to ameliorate the acute injurious effects of acetaminophen on the liver. APAP toxicity was induced in mice by an intraperitoneal injection of APAP (400 mg/kg). The effect of treatment with sitagliptin, initiated 5 days prior to APAP injection, was evaluated. Serum indices of hepatotoxicity, oxidative stress markers in liver tissues, serum IL-1β, and TNF-α in addition to hepatic- NF-E2-related factor-2 (Nrf2) were determined. Our results showed that APAP induced marked hepatic injury as evidenced by an increase in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Acetaminophen; Dipeptidyl peptidase-4 inhibitors; Hepatotoxicity; Nrf2; Sitagliptin. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100610 Registros recuperados: 2 Primeira ... 1 ... Última

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