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	Provedor de dados BJPS (1) Genet. Mol. Biol. (1) Autor Catanesi,Cecilia Inés (1) Ibrahim,Muslih Abdulkarim (1) Ismail,Rusli (1) López Soto,Eduardo Javier (1) Mohamad,Nasir (1) Musa,Nurfadhlina (1) Tan,Soo Choon (1) Zahari,Zalina (1) Mais... Palavra-chave OPRM1 (2) A118G (1) AMOVA (1) Opioid receptors /m analysis (1) Pittsburgh Sleep Quality Index (1) Polymorphism (1) Population genetics (1) SNPs (1) Sleep quality (1) Sleep-Wake Transition Disorders (1) Sleep/genetic (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/report (1) Ano 2018 (1) 2015 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Human population genetic structure detected by pain-related mu opioid receptor gene polymorphisms Genet. Mol. Biol. López Soto,Eduardo Javier; Catanesi,Cecilia Inés. Several single nucleotide polymorphisms (SNPs) in the Mu Opioid Receptor gene (OPRM1) have been identified and associated with a wide variety of clinical phenotypes related both to pain sensitivity and analgesic requirements. The A118G and other potentially functional OPRM1 SNPs show significant differences in their allele distributions among populations. However, they have not been properly addressed in a population genetic analysis. Population stratification could lead to erroneous conclusions when they are not taken into account in association studies. The aim of our study was to analyze OPRM1 SNP variability by comparing population samples of the International Hap Map database and to analyze a new population sample from the city of Corrientes,... Tipo: Info:eu-repo/semantics/report Palavras-chave: OPRM1; SNPs; A118G; AMOVA; Population genetics. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000200152 Sleep quality and OPRM1 polymorphisms: a cross-sectional study among opioid-naive individuals BJPS Zahari,Zalina; Ibrahim,Muslih Abdulkarim; Musa,Nurfadhlina; Tan,Soo Choon; Mohamad,Nasir; Ismail,Rusli. ABSTRACT Opioidergic system involves in regulation of sleep and wakefulness. It is possible, therefore, that genetic polymorphisms in OPRM1 influence sleep quality. This study investigated the association of OPRM1 polymorphisms with subjective sleep quality among opioid-naive individuals. This cross-sectional observational study involved 161 opioid-naive males (mean age = 27.74 years; range: 18−63 years). Subjective sleep quality was assessed with the translated and validated Malay version of the Pittsburgh Sleep Quality Index (PSQI). DNA was extracted from whole blood and subjected to polymerase chain reaction (PCR)-genotyping for two OPRM1 polymorphisms (118A>G and IVS2+691G>C). Subjects with combined 118A and IVS2+691G alleles (AC haplotype) had... Tipo: Info:eu-repo/semantics/article Palavras-chave: Sleep-Wake Transition Disorders; Sleep quality; Sleep/genetic; Polymorphism; Pittsburgh Sleep Quality Index; OPRM1; Opioid receptors /m analysis. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000100610 Registros recuperados: 2 Primeira ... 1 ... Última

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