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Role of endogenous glucocorticoids in hyperalgesia and edema in old arthritic rats BJMBR
Yokoro,C.M.; Tatsuo,M.A.K.F.; Pereira,L.S.M.; Alves,D.L.F.; Francischi,J.N..
We compared the intensity and frequency of arthritis in old (8-12 months, N = 12) and juvenile (2 months, N = 10) rats and determined the role played by adrenal glands in this disorder. Arthritis was induced by subcutaneous injection of Mycobacterium butyricum at the base of the tail of female Holtzman rats at day zero. Paw edema and hyperalgesia were monitored from day zero to day 21 after induction as signs of arthritis development. Some (N = 11) old animals were adrenalectomized bilaterally and treated with dexamethasone or celecoxib immediately following surgery. All bilaterally adrenalectomized old animals became susceptible to arthritis and the onset of disease was shortened from the 10th to the 5th day. Hyperalgesia and paw edema responses were less...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hyperalgesia; Edema; Adjuvant arthritis; Adrenalectomy; Dexamethasone; Old rats.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000100011
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