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Genistein affects the morphology of pituitary ACTH cells and decreases circulating levels of ACTH and corticosterone in middle-aged male rats Biol. Res.
AJDŽANOVI,VLADIMIR Z; ŠOŠI-JURJEVI,BRANKA T; FILIPÓVI,BRANKO R; TRIFUNOVI,SVETLANA L; BRKIC,DEJAN D; SEKULI,MILKA I; MILOSEVI,VERICA LJ.
The soybean phytoestrogen, genistein, is increasingly consumed as an alternative therapeutic for age-related diseases, namely cardiovascular conditions, cancer and osteoporosis. However, despite the beneficial effects on health, concern has been raised that this isoflavone also acts as an endocrine-disrupting chemical. The aim of this study was to examine the effects of genistein on immunohistomorphometric features of pituitary adrenocorticotropic cells (ACTH) and blood concentrations of ACTH and corticosterone in orchidectomized middle-aged male rats. Sixteen-month-old Wistar rats were divided into sham-operated (SO), orchidectomized (Orx) and genistein-treated orchidectomized (Orx+G) groups. Genistein (30mg/kg/day) was administered subcutaneously for...
Tipo: Journal article Palavras-chave: ACTH cells; Corticosterone; Genistein; Middle-age; Orchidectomy; Rats.
Ano: 2009 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000100002
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Peripubertal orchidectomy transitorily affects age-associated thymic involution in rats BJMBR
Pesic,V.; Radojevic,K.; Kosec,D.; Plecas-Solarovic,B.; Perisic,M.; Pilipovic,I.; Leposavic,G..
The role of gonadal hormones in induction and, particularly, maintenance/progression of rat thymic involution, which normally starts around puberty, was reassessed by examining the effects of peripubertal orchidectomy on thymic weight and morphometric parameters at different times up to the age of 10 months. Up to 6 months post-castration both thymic weight and cellularity in orchidectomized (Cx) rats were greater than in age-matched control rats, sham Cx (Sx). The increase in thymic cellularity reflected an increase in thymocyte proliferation rate (the proportion of proliferating cells was 18.6 ± 0.7% in 2-month-old Cx (N = 5) vs 13.4 ± 0.3% (N = 5) in age-matched Sx rats) followed by reduced sensitivity to apoptotic signals (apoptotic thymocytes were 9.8...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rat thymus; Aging; Orchidectomy; Stereological analysis; Thymocyte proliferation; Thymocyte apoptosis.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100009
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