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Bone resorptive activity of osteoclast-like cells generated in vitro by PEG-induced macrophage fusion Biol. Res.
Murillo,Andrea; Guerrero,Carlos A; Acosta,Orlando; Cardozo,Carmen A.
Normal bone remodeling is maintained by a balance between osteoclast and osteoblast activity, whereas defects in osteoclast activity affecting such balance result in metabolic bone disease. Macrophage-macrophage fusion leading to multinucleated osteoclasts being formed is still not well understood. Here we present PEG-induced fusion of macrophages from both U937/A and J774 cell lines and the induced differentiation and activation of osteoclast-like cells according to the expression of osteoclast markers such as tartrate resistant acid phosphatase (TRAP) and bone resorptive activity. PEG-induced macrophage fusion, during the non-confuent stage, signifcantly increased the osteoclastogenic activity of macrophages from cell lines compared to that of...
Tipo: Journal article Palavras-chave: Bone resorption; Macrophage fusion; Osteoclast activity; Osteoclast differentiation; PEG; RANKL.
Ano: 2010 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000200009
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