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| Volpini,R.A.; Balbi,A.P.C.; Costa,R.S.; Coimbra,T.M.. |
| Mitogen-activated protein kinases (MAPK) may be involved in the pathogenesis of acute renal failure. This study investigated the expression of p-p38 MAPK and nuclear factor kappa B (NF-kappaB) in the renal cortex of rats treated with gentamicin. Twenty rats were injected with gentamicin, 40 mg/kg, im, twice a day for 9 days, 20 with gentamicin + pyrrolidine dithiocarbamate (PDTC, an NF-kappaB inhibitor), 14 with 0.15 M NaCl, im, twice a day for 9 days, and 14 with 0.15 M NaCl , im, twice a day for 9 days and PDTC, 50 mg kg-1 day-1, ip, twice a day for 15 days. The animals were killed 5 and 30 days after the last of the injections and the kidneys were removed for histological, immunohistochemical and Western blot analysis and for nitrate determination. The... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: P38 mitogen-activated protein kinase; Nuclear factor-kappaB; Inflammation; Renal fibrosis; Gentamicin-induced acute tubular necrosis; Nitric oxide. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000600016 |
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| Yang,Zheng; Zhang,Hui; An,Ming; Bian,Mengni; Song,Miao; Guo,Xiaohua; Liu,Quanli; Qiu,Min. |
| Total Panax notoginseng saponin (TPNS) is the main bioactivity compound derived from the roots and rhizomes of Panax notoginseng (Burk.) F.H. Chen. The aim of this study was to investigate the effectiveness of TPNS in treating vascular neointimal hyperplasia in rats and its mechanisms. Male Sprague-Dawley rats were randomly divided into five groups, sham (control), injury, and low, medium, and high dose TPNS (5, 10, and 20 mg/kg). An in vivo 2F Fogarty balloon-induced carotid artery injury model was established in rats. TPNS significantly and dose-dependently reduced balloon injury-induced neointimal area (NIA) (P<0.001, for all doses) and NIA/media area (MA) (P<0.030, for all doses) in the carotid artery of rats, and PCNA expression (P<0.001,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Total Panax notoginseng saponin; Neointimal hyperplasia; Vascular injury; Phosphorylated extracellular signal-regulated kinase1/2; P38 mitogen-activated protein kinase. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000100606 |
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