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| Faleiro,M.B.R.; Cintra,L.C.; Jesuino,R.S.A.; Damasceno,A.D.; Moura,V.M.B.D.. |
| ABSTRACT Gene expression of CDKN1A, CDKN1B, and TP53, and immunostaining of p21, p27 and p53 were evaluated to verify the role of these cell cycle inhibitors in canine prostates with proliferative inflammatory atrophy-PIA and prostatic carcinoma-PC. Seventy samples, 15 normal, 30PIA and 25PC. Regarding number of p27 and p53 labeled cells, difference between normal and PIA and PC was observed, as well as between PIA and PC for p53. Immunostaining intensities of p21, p27 and p53 were different when comparing normal tissues to PIA and PC. Sixteen cDNA of canine prostatic FFPE tissue were subjected to RT-PCR and RT-qPCR, four normal, three PIA, and nine PC. CDKN1A mRNA was detected in four PC by RT-PCR, and it was overexpressed when compared to normal by... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: P21; P27; P53; PIA; RT-qPCR. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352018000100082 |
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| Toledo,Denise Caroline; Faleiro,Mariana Batista Rodrigues; Rodrigues,Marcela Marcondes Pinto; Di Santis,Giovana Wingeter; Amorim,Renée Laufer; Moura,Veridiana Maria Brianezi Dignani de. |
| A atrofia inflamatória proliferativa (PIA) é uma lesão prostática pré-maligna de grande ocorrência na próstata humana e, mais recentemente, também observada em cães. Esta pesquisa teve por objetivo verificar os aspectos histomorfológicos da PIA na próstata canina. Foram utilizadas 43 próstatas de cães adultos, de várias raças e portes, e com histórico ou não de doença prostática. Os focos de PIA apresentaram epitélio displásico, formado por ácinos atróficos e com mais de uma camada de células de morfologia atípica, especialmente anisocitose, anisocariose, citoplasma reduzido, núcleo volumoso e com nucléolo evidente. As alterações epiteliais eram sempre acompanhadas de infiltrado inflamatório intersticial periacinar predominantemente linfocitário. Foi... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cão; PIA; Displasia prostática. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782010000600021 |
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| Faleiro,Mariana Batista Rodrigues; Cintra,Lorena Cardoso; Jesuino,Rosália Santos Amorim; Araújo,Eugênio Gonçalves de; Rocha,Rafael Malagoli; Moura,Veridiana Maria Brianezi Dignani de. |
| ABSTRACT: Gene expression of ErbB1 and ErbB2, and immunostaining of EGFR (Her1) and Her2 (c-erbB-2) were evaluated in this study to ascertain whether these receptors are involved in the evolution of canine premalignant and malignant prostatic lesions, as proliferative inflammatory atrophy (PIA) and prostatic carcinoma (PC). With regards to the intensity of EGFR immunostaining, there was no difference between normal prostatic tissue and tissues with PIA or PC. In relation to Her2 immunostaining, there were differences between normal prostatic tissue and those with PIA and PC, as also differences between prostates with PIA and PC. There was no correlation between EGFR and Her2 immunostaining. ErbB1 gene product was detected in two normal tissue samples, in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Growth factor receptor; Her1; C-erbB-2; PIA; RT-PCR. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017001200553 |
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