| In horses, insulin resistance is associated with several comorbidities such as obesity, laminitis, colic and osteochondrosis. The multifactorial causes of insulin resistance in horses have been addressed, which include genetic and environmental factors. As a consequence of these factors, the cellular signaling pathways responsible for insulin synthesis, the glucose intake in target cells of peripheral tissues and other related processes (e.g., adipocytokine signaling pathways) are affected. In response to insulin, changes in gene expression occur, which are required for the integration of an entire network of metabolic and physiological responses in different organs. The peroxisome proliferator-activated receptors (PPARs) were the particular focus of... |
