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	Provedor de dados BJMBR (2) Autor Chen,Yangmei (1) Fleck,J. (1) He,Miaoqing (1) Jesse,A.C. (1) Li,Rong (1) Marafiga,J.R. (1) Mello,C.F. (1) Milanesi,L.H. (1) Rambo,L.M. (1) Temp,F.R. (1) Wu,Bing (1) Zhang,Peng (1) Zhang,Qinbin (1) Mais... Palavra-chave PTZ (2) AMPA receptor (1) CysLT1R (1) CysLT2R (1) Kindling (1) Montelukast (1) SAD-B (1) Seizure (1) Temporal lobe epilepsy (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2020 (1) 2016 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última SAD-B modulates epileptic seizure by regulating AMPA receptors in patients with temporal lobe epilepsy and in the PTZ-induced epileptic model BJMBR Li,Rong; He,Miaoqing; Wu,Bing; Zhang,Peng; Zhang,Qinbin; Chen,Yangmei. α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are the predominant mediators of glutamate-induced excitatory neurotransmission. It is widely accepted that AMPA receptors are critical for the generation and spread of epileptic seizure activity. Dysfunction of AMPA receptors as a causal factor in patients with intractable epilepsy results in neurotransmission failure. Brain-specific serine/threonine-protein kinase 1 (SAD-B), a serine-threonine kinase specifically expressed in the brain, has been shown to regulate AMPA receptor-mediated neurotransmission through a presynaptic mechanism. In cultured rat hippocampal neurons, the overexpression of SAD-B significantly increases the frequency of miniature excitatory postsynaptic currents... Tipo: Info:eu-repo/semantics/article Palavras-chave: SAD-B; AMPA receptor; Temporal lobe epilepsy; PTZ. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000400602 Montelukast reduces seizures in pentylenetetrazol-kindled mice BJMBR Fleck,J.; Temp,F.R.; Marafiga,J.R.; Jesse,A.C.; Milanesi,L.H.; Rambo,L.M.; Mello,C.F.. Cysteinyl leukotrienes (CysLTs) have been implicated in seizures and kindling; however, the effect of CysLT receptor antagonists on seizure frequency in kindled animals and changes in CysLT receptor expression after pentylenetetrazol (PTZ)-induced kindling have not been investigated. In this study, we evaluated whether the CysLT1 inverse agonist montelukast, and a classical anticonvulsant, phenobarbital, were able to reduce seizures in PTZ-kindled mice and alter CysLT receptor expression. Montelukast (10 mg/kg, sc) and phenobarbital (20 mg/kg, sc) increased the latency to generalized seizures in kindled mice. Montelukast increased CysLT1immunoreactivity only in non-kindled, PTZ-challenged mice. Interestingly, PTZ challenge decreased CysLT2 immunoreactivity... Tipo: Info:eu-repo/semantics/article Palavras-chave: Montelukast; CysLT1R; CysLT2R; Seizure; PTZ; Kindling. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000400602 Registros recuperados: 2 Primeira ... 1 ... Última

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