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	Provedor de dados BJPS (2) Autor Chafle,Sandip Annaji (1) Khobragade,Deepak Shamrao (1) Kohli,Kanchan (1) Lakhotia,Champalal Laxminarayan (1) Pai,Raveendra (1) Patil,Arun Trambak (1) Shrivastava,Birendra (1) Ujjainkar,Amol Prasadrao (1) Umathe,Sudhir Niranjanrao (1) Mais... Palavra-chave Pellets/evaluation (2) Diclofenac sodium/coating (1) Diclofenac sodium/pellets (1) Disintegration pH (1) Enteric coating/evaluation (1) Extrusion/spheronization technique (1) Hot-melt coating/evaluation (1) Palmitic acid/coating (1) Palmitic acid/pellets (1) Pellets/coating (1) Pellets/compression (1) Pellets/extended release (1) Pellets/obtention (1) Stearic acid/coating (1) Stearic acid/pellets (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2012 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Compression and evaluation of extended release matrix pellets prepared by the extrusion/spheronization process into disintegrating tablets BJPS Pai,Raveendra; Kohli,Kanchan; Shrivastava,Birendra. In this study, a novel approach for compression of matrix pellets into disintegrating tablets has been studied in an attempt to overcome the issues pertaining to rupture of polymer coat during compression of reservoir-type pellets. Extended release matrix pellets were prepared by the extrusion/spheronization technique using commercially available aqueous dispersions of ethyl cellulose, acrylic polymers and sodium alginate at 10%, 20% and 30%w/w levels. Sertraline hydrochloride was used as the model drug and an in vitro release profile of 12 h was targeted. Tablets containing matrix pellets were prepared by the direct compression process. Acceptance Value, a pharmacopeial test, was applied to study the uniformity of drug distribution. Effect of compression... Tipo: Info:eu-repo/semantics/article Palavras-chave: Pellets/extended release; Pellets/evaluation; Pellets/obtention; Pellets/compression; Extrusion/spheronization technique. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000100014 Development and evaluation of a hot-melt coating technique for enteric coating BJPS Patil,Arun Trambak; Khobragade,Deepak Shamrao; Chafle,Sandip Annaji; Ujjainkar,Amol Prasadrao; Umathe,Sudhir Niranjanrao; Lakhotia,Champalal Laxminarayan. Conventional enteric coating requires the use of organic based polymers which are equally hazardous to the environment and operating personnel. Hot-melt coating avoids the use of solvents and is a safer and time-saving process. The present study was designed to assess the efficacy of hot-melt coating (HMC) as an enteric coating technique. Pellets prepared by extrusion spheronization were selected as the core formulation for a model of the gastric irritant drug diclofenac sodium (DFS) because of their innate advantages over single-unit formulations. Stearic acid (SA) and palmitic acid (PA) were evaluated as enteric hot-melt coating materials. HMC was carried out in a specially modified coating pan by applying SA and PA in molten state onto preheated pellets... Tipo: Info:eu-repo/semantics/article Palavras-chave: Pellets/coating; Pellets/evaluation; Enteric coating/evaluation; Hot-melt coating/evaluation; Disintegration pH; Diclofenac sodium/pellets; Diclofenac sodium/coating; Palmitic acid/pellets; Palmitic acid/coating; Stearic acid/pellets; Stearic acid/coating. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000100008 Registros recuperados: 2 Primeira ... 1 ... Última

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