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	Provedor de dados BJMBR (2) Autor Duarte,I.D.G. (2) Castro,M.S.A. (1) Francischi,J.N. (1) Guzzo,L.S. (1) Perez,A.C. (1) Rodrigues,A.R.A. (1) Romero,T.R.L. (1) Silva,L.C.R. (1) Mais... Palavra-chave Peripheral antinociception (2) Cannabinoid system (1) Fentanyl (1) Glibenclamide (1) K+ channel (1) Nonsteroidal anti-inflammatory drugs (NSAIDs) (1) Μ-Opioid receptor agonist (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2012 (1) 2005 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Participation of cannabinoid receptors in peripheral nociception induced by some NSAIDs BJMBR Silva,L.C.R.; Romero,T.R.L.; Guzzo,L.S.; Duarte,I.D.G.. Nonsteroidal anti-inflammatory drugs (NSAIDs) have been used extensively to control inflammatory pain. Several peripheral antinociceptive mechanisms have been described, such as opioid system and NO/cGMP/KATP pathway activation. There is evidence that the cannabinoid system can also contribute to the in vivo pharmacological effects of ibuprofen and indomethacin. However, there is no evidence of the involvement of the endocannabinoid system in the peripheral antinociception induced by NSAIDs. Thus, the aim of this study was to investigate the participation of the endocannabinoid system in the peripheral antinociceptive effect of NSAIDs. All experiments were performed on male Wistar rats (160-200 g; N = 4 per group). Hyperalgesia was induced by a... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nonsteroidal anti-inflammatory drugs (NSAIDs); Peripheral antinociception; Cannabinoid system. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200018 Participation of ATP-sensitive K+ channels in the peripheral antinociceptive effect of fentanyl in rats BJMBR Rodrigues,A.R.A.; Castro,M.S.A.; Francischi,J.N.; Perez,A.C.; Duarte,I.D.G.. We examined the effect of several K+ channel blockers such as glibenclamide, tolbutamide, charybdotoxin (ChTX), apamin, tetraethylammonium chloride (TEA), 4-aminopyridine (4-AP), and cesium on the ability of fentanyl, a clinically used selective µ-opioid receptor agonist, to promote peripheral antinociception. Antinociception was measured by the paw pressure test in male Wistar rats weighing 180-250 g (N = 5 animals per group). Carrageenan (250 µg/paw) decreased the threshold of responsiveness to noxious pressure (delta = 188.1 ± 5.3 g). This mechanical hyperalgesia was reduced by fentanyl (0.5, 1.5 and 3 µg/paw) in a peripherally mediated and dose-dependent fashion (17.3, 45.3 and 62.6%, respectively). The selective blockers of ATP-sensitive K+ channels... Tipo: Info:eu-repo/semantics/article Palavras-chave: Peripheral antinociception; Fentanyl; K+ channel; Μ-Opioid receptor agonist; Glibenclamide. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000100014 Registros recuperados: 2 Primeira ... 1 ... Última

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