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Polypropylene meshes coated with chitosan/polyethylene glycol for the reconstruction of the abdominal wall: an experimental study in rats Arq. Bras. Med. Vet. Zootec.
Rodrigues,D.F.; Mendes,F.F.; Melo,R.M.; Menezes,L.B.; Guimarães,L.L.B.; Silva,A.S.; Rammazzina Filho,W.A.; Moraes,A.M.; Paulo,N.M..
ABSTRACT The aim of this study was to characterize the tissue reactions triggered by the polypropylene mesh coated with chitosan and polyethylene glycol film, and if it’s able to prevent the formation of peritoneal adhesions. Defects in the abdominal wall of rats were induced and polypropylene meshes coated with chitosan/polyethylene glycol (CPEG group, n= 12) and uncoated (PP control group, n= 12) were implanted. On the fourth and forty-fifth postoperative day the formation of adhesion and the tissue reaction to the biomaterial was evaluated through histological and histochemical analysis. The area (P= 0.01) and severity (P= 0.002) of the adhesion was significatively less in the CPEG group. On the fourth day the foreign body reaction was less intense in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Foreign-body reaction; Hernia; Peritoneal adhesions; Prosthesis; Surgical mesh.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000401198
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Effect of sodium carboxymethylcellulose and methylprednisolone on the healing of jejunal anastomoses in rats BJMBR
Sousa,A.A.; Petroianu,A.; Trapiello Neto,V.; Rios,V.S.; Barbosa,A.J.A..
Sodium carboxymethylcellulose (SCMC) has been effective in reducing adhesion formation and corticosteroids reduce the inflammatory process. The objective of this study was to define the intraperitoneal (ip) effects of SCMC combined with intramuscular (im) methylprednisolone on peritoneal adhesion formation and on jejunal anastomosis healing in rats. Twenty Wistar rats (200-350 g) were divided into four groups (N = 5): groups I and III (controls) 5 and 21 days of treatment before sacrifice, respectively; groups II and IV (experimental groups) 5 and 21 days of treatment, respectively. SCMC (1%) was infused into the abdominal cavity and methylprednisolone (10 mg kg-1 day-1) was injected im daily from the day before surgery for animals of groups II and IV. All...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bowel anastomosis; Peritoneal adhesions; Sodium carboxymethylcellulose; Corticosteroid; Histology; Wound healing.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000400012
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