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| Olivella,Mónica S.; Debattista,Nora B.; Pappano,Nora B.. |
| Considering the skin´s function, different dermal pharmaceutical forms can be developed according to the type of therapeutic activity, active principle and excipients involved in the formulation, such as transdermal preparations. In the present study, the permeation parameters of the non-steroidal antiinflammatory drug, salicylic acid (SA) through synthetic membrane, polyvinyliden difluoride, and a biological membrane, egg shell membrane, with different vehicles, propylene glycol, isopropyl alcohol and carbopol gel, were determined. The reported physicochemical parameters of SA from CG were significantly higher than those obtained using PG and IP. This is attributed to the lipophilic nature of the vehicle that facilitates the release and penetration of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Membranes; Permeation; Drug release; Salicylic acid. |
| Ano: 2006 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452006000200008 |
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| Freire,Thamires Batello; Dario,Michelli Ferrera; Mendes,Otávio Gil; Oliveira,Andressa Costa de; Vetore Neto,Alberto; Faria,Dalva Lucia Araújo de; Silva,Vânia Rodrigues Leite e; Baby,André Rolim; Velasco,Maria Valéria Robles. |
| The Ginoide Hydrolipodystrophy (GHLD), commonly known as cellulite, occurs in 80-90% of the female population after the puberty period and comes from a metabolic modification in the cutaneous adipose tissue. Caffeine has been used in topical formulations due to its lipolytic action. We studied a nanoemulsion (F3) containing caffeine with two surfactants (oleth-3 and oleth-20) by emulsification method by phase inversion temperature inversion (PIT). The polydispersion indices (PDI) showed the reduced deviation of 0.1. The mean droplet size was ~ 40 nm. The evaluated constant of Ostwald, in the refrigerator condition was the most favorable during the stability test. In the In Raman spectroscopy assay, the caffeine bands found in F3 were compatible with those... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cellulite; Caffeine; Gynoid hydrolipodystrophy; Nanoemulsion; Permeation. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100567 |
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