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	Provedor de dados BJPS (1) Autor Sousa,João J. S. (1) Vaz,Mafalda. B. (1) Vitorino,Carla (1) Palavra-chave Ibuprofen (1) Mechanical properties (1) Permeation studies (1) Safe-by-design (1) Topical patches (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2020 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Safe-by-design development of a topical patch for drug delivery BJPS Vaz,Mafalda. B.; Vitorino,Carla; Sousa,João J. S.. Few topical products have been developed specifically to treat acute and chronic arthritis and inflammation, using non-steroidal anti-inflammatory drugs (NSAIDs). The lack of dosing accuracy commonly found in locally applied semisolid products for cutaneous use is a critical issue that leads to treatment failure. The aim of the present work is to develop a differentiated and innovative topical patch based on a monolithic hydrogel for ibuprofen skin delivery, in order to provide a safer and accurate way of drug administration along with improved treatment compliance. Topical patches based on hydroxypropylmethylcellulose (HPMC) were optimized in composition, in terms of enhancer and adhesive, supported on a systematic assessment of in vitro release and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Topical patches; Ibuprofen; Mechanical properties; Permeation studies; Safe-by-design. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100626 Registros recuperados: 1 Primeira ... 1 ... Última

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