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	Provedor de dados J. Venom. Anim. Toxins incl. Trop. Dis. (1) Autor Bagheri,Masoumeh (1) Goudarzi,Hamidreza (1) Najafabadi,Zahra Salehi (1) Sajadi,Mahnaz (1) Shahbazi,Benyamin (1) Tahoori,Fatemeh (1) Mais... Palavra-chave Apoptosis (1) Cytotoxicity (1) HPLC fractions (1) Persian horned viper (1) Pseudocerastes persicus venom (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2019 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Cytotoxic effects of Pseudocerastes persicus venom and its HPLC fractions on lung cancer cells J. Venom. Anim. Toxins incl. Trop. Dis. Shahbazi,Benyamin; Najafabadi,Zahra Salehi; Goudarzi,Hamidreza; Sajadi,Mahnaz; Tahoori,Fatemeh; Bagheri,Masoumeh. ABSTRACT Background: Several studies have pointed out that certain snake venoms contain compounds presenting cytotoxic activities that selectively interfere with cancer cell metabolism. In this study, Pseudocerastes persicus venom and its fractions were investigated for their anticancer potential on lung cancer cells. Methods: Lung cancer cells (A549) and normal fibroblast cells (Hu02) were treated with the P. persicus venom and its HPLC fractions and the cell cytotoxic effects were analyzed using MTT and lactate dehydrogenase release assays. Apoptosis was determined in venom-treated cell cultures using caspase-3 and caspase-9 assay kits. Results: The treatment of cells with HPLC fraction 21 (25-35 kDa) of P. persicus venom resulted in high LDH... Tipo: Info:eu-repo/semantics/article Palavras-chave: Pseudocerastes persicus venom; Persian horned viper; HPLC fractions; Cytotoxicity; Apoptosis. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100319 Registros recuperados: 1 Primeira ... 1 ... Última

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