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Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems Anais da ABC (AABC)
Moreira,Maria Elisabete C.; Barcinski,Marcello A..
Cell death by apoptosis is characterized by specific biochemical changes, including the exposure of multiple ligands, expected to tag the dying cell for prompt recognition by phagocytes. In non-pathological conditions, an efficient clearance is assured by the redundant interaction between apoptotic cell ligands and multiple receptor molecules present on the engulfing cell surface. This review concentrates on the molecular interactions operating in mammalian and non-mammalian systems for apoptotic cell recognition, as well as on the consequences of their signaling. Furthermore, some cellular models where the exposure of the phosphatidylserine (PS) phospholipid, a classical hallmark of the apoptotic phenotype, is not followed by cell death will be discussed.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cell death; Apoptosis; Apoptotic cell recognition; Apoptotic mimicry; Phagocyte; Intracellular signaling.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000100009
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Apoptotic mimicry: an altruistic behavior in host/Leishmania interplay BJMBR
Wanderley,J.L.M.; Benjamin,A.; Real,F.; Bonomo,A.; Moreira,M.E.C.; Barcinski,M.A..
Apoptosis is the most common phenotype observed when cells die through programmed cell death. The morphologic and biochemical changes that characterize apoptotic cells depend on the activation of a diverse set of genes. Apoptosis is essential for multicellular organisms since their development and homeostasis are dependent on extensive cell renewal. In fact, there is strong evidence for the correlation between the emergence of multicellular organisms and apoptosis during evolution. On the other hand, no obvious advantages can be envisaged for unicellular organisms to carry the complex machinery required for programmed cell death. However, accumulating evidence shows that free-living and parasitic protozoa as well as yeasts display apoptotic markers. This...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Apoptosis; Phosphatidylserine; Leishmania; Phagocyte.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000600001
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