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Application of redox reactions for the determination of valganciclovir hydrochloride in pharmaceuticals BJPS
Qarah,Nagib Abdullah Salem; Basavaiah,Kanakapura; Abdulrahman,Sameer Abdulaziz Mohammed.
Two simple, selective and sensitive spectrophotometric methods were developed and validated for the determination of valganciclovir hydrochloride (VLGH) in pure drug and tablets. The first method was based on the reduction of iron(III) to iron(II) by VLGH and subsequent formation of iron(III)-ferricyanide complex (Prussian blue) in acid medium which was measured at 730 nm (method A). In the second method (method B), permanganate was reduced by VLGH to bluish green manganate in alkaline medium and the absorbance was measured at 610 nm. The absorbance measured in each case was related to VLGH concentration. The experimental conditions were carefully studied and optimized. Beer’s law was obeyed over the concentration ranges of 2.5-20.0 and 2.0-40.0 µg mL-1...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Valganciclovir hydrochloride/determination; Spectrophotometry/method validation; Pharmaceutical formulations.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100516
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