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| Oliveira,Marcelo Antonio de; Lacerda,Caroline Dutra; Bonella,André Fazôlo. |
| Atorvastatin (ATV) is an antilipemic drug of great interest to the pharmaceutical industry. ATV does not appear in the monographs of Brazilian pharmacopoeia, and analytical methodologies for its determination have been validated. The chromatographic conditions used included: RP-18 column-octadecylsilane (250 x 4.6 mm, 5 mm), detection at 238 nm, mobile phase containing 0.1% phosphoric acid and acetonitrile (35:65% v/v), flow at 1.5 mL min-1, oven temperature at 30ºC, and injection volume of 10 mL. ATV is classified as a class II product, according to the biopharmaceutical classification system. As such, a dissolution test was proposed to evaluate pharmaceutical formulations on the market today, under the following conditions: water as a dissolution medium,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pharmaceutical formulations/evaluation; Atorvastatin; Drugs/dissolution test; Drugs/qualitative analysis. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400024 |
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| Tiwari,Ruchi; Srivastava,Birendra; Tiwari,Gaurav; Rai,Awanik. |
| The present study investigated a novel extended release system of promethazine hydrochloride (PHC) with acrylic polymers Eudragit RL100 and Eudragit S100 in different weight ratios (1:1 and 1: 5), and in combination (0.5+1.5), using freeze-drying and spray-drying techniques. Solid dispersions were characterized by Fourier-transformed infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), Powder X-ray diffractometry (PXRD), Nuclear magnetic resonance (NMR), Scanning electron microscopy (SEM), as well as solubility and in vitro dissolution studies in 0.1 N HCl (pH 1.2), double-distilled water and phosphate buffer (pH 7.4). Adsorption tests from drug solution to solid polymers were also performed. A selected solid dispersion system was... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Promethazine hydrochloride/extended release; Drugs/extended release; Eudragit RL100; Eudragit S100; Acrylic polymers; Spray drying/pharmacotechnics; Freeze drying/pharmacotechnics; Extended realease/pharmacotechnics; Pharmaceutical formulations/evaluation. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400029 |
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