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	Provedor de dados BJPS (4) Autor Ribeiro,Paulo Roberto da Silva (2) Avachat,Amelia M. (1) Duarte,Reginária Morais (1) Jadhav,Priyanka S. (1) Jamkar,Priti M. (1) Lima,Liliane Spazzapam (1) Pezza,Helena Redigolo (1) Pezza,Leonardo (1) Somasekhar,Vanita (1) Tubino,Matthieu (1) Mais... Palavra-chave Pharmaceutical formulations/quality control (4) 6-Mercaptopurine/determination (1) Atorvastatin calcium/determination (1) Celecoxib/determination (1) Drugs/dosage (1) Drugs/quantitative analysis (1) High perfomance liquid chromatography/reverse phase/quantitative analysis (1) High performance liquid chromatography/quality control (1) Instrumentation/drugs dosage (1) Methyldopa/spectrophotometric determination (1) Niosomal formulation/quality control (1) Optical sensor/application/colorimetric analysis (1) Spectrophotometry/qualitative analysis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (4) Ano 2015 (2) 2014 (2) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Development and application of a portable instrument for drugs analysis in pharmaceutical preparations BJPS Ribeiro,Paulo Roberto da Silva; Pezza,Helena Redigolo; Pezza,Leonardo; Lima,Liliane Spazzapam; Tubino,Matthieu. This article describes the application and performance of an inexpensive, simple and portable device for colorimetric quantitative determination of drugs in pharmaceutical preparations. The sensor is a light detector resistor (LDR) incorporated into a black PTFE cell and coupled to a low-cost multimeter (Ohmmeter). Quantitative studies were performed with captopril/p-chloranil/H2O2 and methyldopa/ammonium molybdate systems. Calibration curves were obtained by plotting the electrical resistance of the LDR against the concentration of the colored species in the ranges 1.84 × 10-4 to 1.29 × 10-3mol L-1 and 5.04 × 10-4 to 2.52 × 10-3 mol L-1 for captopril/p-chloranil/H2O2 and methyldopa/ammonium molybdate systems, respectively, exhibiting good coefficients of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Optical sensor/application/colorimetric analysis; Instrumentation/drugs dosage; Drugs/quantitative analysis; Drugs/dosage; Pharmaceutical formulations/quality control. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300699 Optimization and validation of an RP-HPLC method for the estimation of 6-mercaptopurine in bulk and pharmaceutical formulations BJPS Somasekhar,Vanita. A reverse phase HPLC method is described for the determination of 6-mercaptopurine in bulk and tablets. Chromatography was carried on a C18 column using a mixture of acetonitrile and 0.05 mol/L sodium acetate buffer (10:90 v/v) as the mobile phase at a flow rate of 1 mL/min-1 with detection at 324 nm. The retention time of the drug was 3.25 min. The detector response was linear in the concentration of 0.01-5 μg/mL. The limit of detection and limit of quantification were 17 and 52 ng/mL respectively. The method was validated by determining its sensitivity, linearity, accuracy and precision. The proposed method is simple, economical, fast, accurate and precise and hence can be applied for routine quality control of mercaptopurine in bulk and tablets. Tipo: Info:eu-repo/semantics/article Palavras-chave: 6-Mercaptopurine/determination; High perfomance liquid chromatography/reverse phase/quantitative analysis; Pharmaceutical formulations/quality control. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400793 Stability indicating method development and validation for simultaneous estimation of atorvastatin calcium and celecoxib in bulk and niosomal formulation by RP-HPLC BJPS Jadhav,Priyanka S.; Jamkar,Priti M.; Avachat,Amelia M.. The present work describes development and validation of a specific, sensitive, precise and stability-indicating high-performance liquid chromatographic method of analysis of atorvastatin calcium and celecoxib, both as a bulk drug and in niosomal formulation. The analysis has been performed by using Cosmosil-C18 column (4.6 mm´250 mm, 5 m) at 25 °C using acetonitrile: ammonium acetate buffer pH 5.0: methanol (50:25:25 v/v/v) as mobile phase. The detection was carried out at 277nm with a flow rate of 1.0mL/min. The retention times of Atorvastatin calcium and Celecoxib were 6.195 and 3.989min, respectively. The method was validated according to ICH guidelines, for specificity, precision, linearity, accuracy and robustness. Atorvastatin calcium and Celecoxib... Tipo: Info:eu-repo/semantics/article Palavras-chave: Atorvastatin calcium/determination; Celecoxib/determination; High performance liquid chromatography/quality control; Niosomal formulation/quality control; Pharmaceutical formulations/quality control. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300653 Development and validation of a simple spectrophotometric method for the determination of methyldopa in both bulk and marketed dosage formulations BJPS Ribeiro,Paulo Roberto da Silva; Duarte,Reginária Morais. A simple, precise, sensitive, rapid, specific and economical spectrophotometric method was developed to determine methyldopa (MTD) content in bulk and pharmaceutical dosage formulations. The proposed method was based on the formation of a colored product from the nitrosation reaction of MTD with sodium nitrite in an acid medium. The resultant nitroso derivative species reacts further with sodium hydroxide and is converted it into a more stable compound. This yellow nitrosation product exhibited an absorption maximum at 430 nm. Beer's Law was obeyed in a concentration range of 6.37 to 82.81 μg mL-1 MTD with an excellent coefficient of determination (R2 = 0.9998). No interference was observed from common excipients in formulations. The results showed the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Methyldopa/spectrophotometric determination; Pharmaceutical formulations/quality control; Spectrophotometry/qualitative analysis. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300573 Registros recuperados: 4 Primeira ... 1 ... Última

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