|
|
|
|
|
| Silva,Gisele Rodrigues da; Fialho,Sílvia Ligório; Siqueira,Rubens Camargo; Jorge,Rodrigo; Cunha Júnior,Armando da Silva. |
| The treatment of diseases affecting the posterior segment of the eye is limited by the difficulty in transporting effective doses of drugs to the vitreous, retina, and choroid. Topically applied drugs are poorly absorbed due to the low permeability of the external ocular tissues and tearing. The blood-retina barrier limits drug diffusion from the systemic blood to the posterior segment, thus high doses of drug are needed to maintain therapeutic levels. In addition, systemic side effects are common. Intraocular injections could be an alternative, but the fast flowing blood supply in this region, associated with rapid clearance rates, causes drug concentration to quickly fall below therapeutic levels. To obtain therapeutic levels over longer time periods,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Implants/biodegradation; Drugs/delivery systems; Drugs/prolonged delivery systems; Pharmaceutical technology. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000300024 |
| |
|
|
| Pascoa,Henrique; Diniz,Danielle Guimarães Almeida; Florentino,Iziara Ferreira; Costa,Elson Alves; Bara,Maria Teresa Freitas. |
| This article reports the development of a pharmaceutical product containing vegetable actives from a Brazilian medicinal plant. The possibility of forming a microemulsion using Pterodon emarginatus ("sucupira") oil was evaluated and the anti-inflammatory potential of this microemulsion was also examined. A formulation was developed using P. emarginatus oil, a mixture of ethoxylated Castor Oil (Ultramone(r) R-540/propylene glycol 2:1) (surfactant/cosurfactant) and distilled water at a ratio of 10:15:75, respectively. The microemulsion which was selected was then subjected to the preliminary stability test and analyzed in terms of average diameter of droplets, pH, zeta potential, and polydispersity index, on the 1st, 7th, 15th, and 30th days after... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pterodon emarginatus; Pterodon emarginatus; Medicinal plants; Microemulsion; Phytomedicine; Pharmaceutical technology. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100117 |
| |
|
|
|
