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	Provedor de dados BJPS (1) Autor Mujahid,Mohammad (1) Rahman,Mohammad Akhlaquer (1) Palavra-chave Bioavailability (1) Oral delivery (1) Phase diagrams (1) SNEDDS (1) Solubility (1) Thermodynamic stability (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2018 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Development of self-nanoemulsifying tablet (SNET) for bioavailability enhancement of sertraline BJPS Rahman,Mohammad Akhlaquer; Mujahid,Mohammad. Abstract The purpose of the study was to combine the advantages of self-nanoemulsifying drug delivery systems and tablets as a conventional dosage form. Self-nanoemulsifying drug delivery system (SNEDDS) was prepared to enhance the solubility and thus oral bioavailability of sertraline. Aqueous titration method was used to prepare the liquid SNEDDS; ternary phase diagrams were constructed and based on smaller droplet size (24.8 nm), minimum viscosity (153.63 cP) and polydispersity index (0.182), higher percentage transmittance (95%) and in vitro drug release (97%), an optimum system was designated. Liquid SNEDDS was transformed into free-flowing powder by solid adsorption technique followed by compression into tablets. In vitro release of sertraline from... Tipo: Info:eu-repo/semantics/article Palavras-chave: SNEDDS; Phase diagrams; Solubility; Thermodynamic stability; Oral delivery; Bioavailability. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000100620 Registros recuperados: 1 Primeira ... 1 ... Última

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