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Antidiabetic activity evaluation of Onobrychis species on alloxan-induced diabetic mice BJPS
Ozbek,Hanefi; Acikara,Ozlem Bahadir; Oz,Burcin Ergene; Ozbilgin,Serkan; Kirmizi,Neriman Ipek; Ozrenk,Bade Cevriye; Tekin,Mehmet; Saltan,Gulcin.
In the current study, four Onobrychis species, O. albiflora Hub.-Mor., O. argyrea Boiss. subsp. argyrea Boiss., O. galegifolia Boiss., and O. tournefortii (Willd.) Desv. were collected from Anatolia to be evaluated for their antidiabetic activities. Methanol water extracts of the aerial parts were used for experiments. An alloxan-induced diabetic mice test model was used. Phytochemical analysis of the tested extracts was investigated using the HPLC method. The highest activity was observed with treatment of O. albiflora aerial part extract. Significant decrements were detected in the blood glucose levels as follows: 180.83±47.48 and 252.83±50.47mg/dL at 100 mg/kg and 200 mg/kg doses of O. albiflora, respectively, when compared to the isotonic saline...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Onobrychis; Antidiabetic activity; Alloxan; Rutin; Isoquercetin; Phytochemical analysis..
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100504
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