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Platelet rich plasma associated with heterologous fresh and thawed chondrocytes on osteochondral lesions of rabbits Arq. Bras. Med. Vet. Zootec.
Filgueiras,R.R.; Del Carlo,R.J.; Alves,N.P.; Viloria,M.I.V.; McManus,C.M.; Castro,M.B.; Filgueiras,F.P.F.; Monteiro,B.S.; Almeida,R.M.; Andrade,R.R..
Chondrocytes obtained from stifle joint of New Zealand White rabbits were cultivated. Half of cells were maintained in culture for later implantation and the others frozen during six months to evaluate viability. A circular osteochondral defect was created in the right stifle of other twenty seven rabbits. The control group (CG) received no treatment. The thawed (TH) and fresh (FH) heterologous groups received, respectively, an implant of cultivated thawed or fresh heterologous chondrocytes associated with platelet rich plasma (PRP). The CG group showed greatest pain and lameness compared to the other groups seven days after the implantation. Microscopically, at 45 and 90 days, the TH and FH groups showed filling with cartilaginous tissue containing...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rabbits; Articular cartilage; Chondrocyte implantation; Platelet rich plasma; Type II collagen.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352014000100024
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DDS技術を活用した獣医再生治療 OAK
佐々木, 直樹.
Recently, regenerative medicine with autologous cells and tissues has been carried out for tissue regeneration. Basic research and clinical application based on tissue engineering have also been reported in joint cartilage regeneration. The physiological connection between the cartilages newly regenerated and natural ones is not always sufficient. Currently, to tackle the problem, the clinical application of DDS-based cartilage regeneration therapy has been tried. This paper introduces the research results of bone regeneration and articular cartilage regeneration in the veterinary medical field. c 2017, Japan Society of Drug Delivery System. All rights reserved.
Palavras-chave: Basic fibroblast factor; Bone morphogenetic protein; Platelet rich plasma; Transforming growth factor-β1; Β-tricalcium phosphate.
Ano: 2017 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4543
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