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	Provedor de dados BJPS (2) Autor Albuquerque,Sérgio de (1) Araujo,Thalita Pedon de (1) Bedor,Danilo César Galindo (1) Chagas,Stephanye Carolyne Christino (1) Eloy,Josimar Oliveira (1) Leal,Leila Bastos (1) Marchetti,Juliana Maldonado (1) Melo,Elayne Karine Souto de (1) Santana,Davi Pereira de (1) Saraiva,Juliana (1) Silva,José Wellithom Viturino da (1) Mais... Palavra-chave Poloxamer 407 (2) Chaga's Disease (1) Dermatopharmacokinetic. (1) Metronidazole/drug retention (1) Metronidazole/evaluation (1) Rosacea/treatment (1) Sodium caprate (1) Solid dispersions (1) Ursolic acid (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2017 (1) 2015 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Preparation, characterization and evaluation of the in vivo trypanocidal activity of ursolic acid-loaded solid dispersion with poloxamer 407 and sodium caprate BJPS Eloy,Josimar Oliveira; Saraiva,Juliana; Albuquerque,Sérgio de; Marchetti,Juliana Maldonado. Ursolic acid is a promising candidate for treatment of Chagas disease; however it has low aqueous solubility and intestinal absorption, which are both limiting factors for bioavailability. Among the strategies to enhance the solubility and dissolution of lipophilic drugs, solid dispersions are growing in popularity. In this study, we employed a mixture of the surfactants poloxamer 407 with sodium caprate to produce a solid dispersion containing ursolic acid aimed at enhancing both drug dissolution and in vivo trypanocidal activity. Compared to the physical mixture, the solid dispersion presented higher bulk density and smaller particle size. Fourier Transform Infrared Spectroscopy results showed hydrogen bonding intermolecular interactions between drug and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ursolic acid; Chaga's Disease; Solid dispersions; Poloxamer 407; Sodium caprate. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100101 Metronidazole thermogel improves retention and decreases permeation through the skin BJPS Melo,Elayne Karine Souto de; Araujo,Thalita Pedon de; Silva,José Wellithom Viturino da; Chagas,Stephanye Carolyne Christino; Bedor,Danilo César Galindo; Santana,Davi Pereira de; Leal,Leila Bastos. ABSTRACT Metronidazole (MTZ) is widely used as the standard antibiotic for the treatment of rosacea and, more recently, is being used off label in Brazilian hospitals for the treatment of wounds. Following oral administration, minimal amounts of active agent reaches the skin and side effects are strongly induced. Consequently, MTZ is currently being applied topically in order to improve the therapeutic efficacy with reduced side effects, with Rozex(r) (RZ) (an MTZ gelled formulation) being the only marketed product. This study examined whether the use of MTZ 0.75% from thermogel formulations could improve drug retention and reduce dermal exposure compared to that by Rozex(r). Following a 21 h permeation study, the highest total amount of MTZ permeated... Tipo: Info:eu-repo/semantics/article Palavras-chave: Metronidazole/evaluation; Metronidazole/drug retention; Poloxamer 407; Rosacea/treatment; Dermatopharmacokinetic.. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200626 Registros recuperados: 2 Primeira ... 1 ... Última

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