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ClonEstiMate, a Bayesian method for quantifying rates of clonality of populations genotyped at two-time steps ArchiMer
Becheler, Ronan; Masson, Jean-pierre; Arnaud-haond, Sophie; Halkett, Fabien; Mariette, Stephanie; Guillemin, Marie-laure; Valero, Myriam; Destombe, Christophe; Stoeckel, Solenn.
Partial clonality is commonly used in Eukaryotes and has large consequences for their evolution and ecology. Assessing accurately the relative importance of clonal versus sexual reproduction matters for studying and managing such species. Here, we proposed a Bayesian approach, ClonEstiMate, to infer rates of clonality c from populations sampled twice over a short time interval, ideally one generation time. The method relies on the likelihood of the transitions between genotype frequencies of ancestral and descendent populations, using an extended Wright-Fisher model explicitly integrating reproductive modes. Our model provides posterior probability distribution of inferred c, given the assumed rates of mutation, as well as inbreeding and selfing when...
Tipo: Text Palavras-chave: Inbreeding; Instantaneous inference; Population genetics model; Rate of asexuality; Selfing.
Ano: 2017 URL: https://archimer.ifremer.fr/doc/00390/50187/50810.pdf
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