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| Gaspar,A.F.; Prado,W.A.. |
| The amplification of pain long after the initial stimulus may be avoided if the treatment of pain is introduced before its initiation. However, conflicting evidence exists about the efficacy of such preemptive analgesia for the management of postoperative pain. This study compares the efficacy of intraplantar administration of indomethacin (a non-selective inhibitor of cyclooxygenase) and MK886 (an inhibitor of 5-lipoxygenase-activating protein), separately or in combination to produce preemptive analgesia in a model of surgical incisional pain in male Wistar rats. All incised rats (5 to 6 rats per group) had allodynia at 2, 6, and 24 h after surgery as evaluated using von Frey filaments. MK886, but not indomethacin (50 to 200 µg/paw), reduced the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Preemptive analgesia; Indomethacin; MK886; Postoperative pain. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000800016 |
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| Coutinho,Alexandre José; Gasser,Beatriz; Rodriguez,Mariana Garcia Kako; Uscategui,Ricardo Andres Ramirez; Santos,Victor José Correia; Tiosso,Caio de Faria; Barros,Felipe Farias Pereira da Câmara; Toniollo,Gilson Hélio. |
| ABSTRACT: In order to use and study minimally invasive techniques to reduce side effects of ovarian-hysterectomy (OHE) in bitches, the aim of this study was to compare time, surgical complications, pain and postoperative inflammatory response, caused by single port videolaparoscopic OHE and traditional miniceliotomy with snook hook. Twenty-four healthy bitches were randomly divided in two groups: videolaparoscopy (Video) and miniceliotomy (MiniLap). Surgical time and complications, pain, need for analgesic rescue, C-reactive protein concentration, glycaemia and voluntary food ingestion were evaluated during 24 hours following the procedure and compared statistically. Surgical time (38±7min), surgical complications (17%), postoperative pain intensity, need... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Videosurgery; C-reactive protein; Glycaemia; Postoperative pain; Surgical complications. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018001000603 |
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