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	Provedor de dados BJMBR (1) Genet. Mol. Biol. (1) Autor Amarante,F. (1) Bagnoli,Vicente R. (1) Costa,Silvia S. (1) Fonseca,Angela M. da (1) Maturana,M.A. (1) Spritzer,P.M. (1) Vianna-Morgante,Angela M. (1) Vilodre,L.C. (1) Mais... Palavra-chave Premature ovarian failure (2) Bone mineral density (1) FMR1 premutation (1) Fragile X syndrome (1) Hypogonadism (1) Menopause (1) Osteoporosis (1) Premature menopause (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2011 (1) 2006 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Women with primary ovarian insufficiency have lower bone mineral density BJMBR Amarante,F.; Vilodre,L.C.; Maturana,M.A.; Spritzer,P.M.. The aim of the present study was to assess the prevalence of osteoporosis in a sample of 32 patients with spontaneous primary ovarian insufficiency (POI) in comparison to reference groups of 25 pre- and 55 postmenopausal women. Hip (lumbar) and spinal bone mineral density (BMD) measurements were performed by dual-energy X-ray absorptiometry in the three groups. The median age of POI patients at the time of diagnosis was 35 years (interquartile range: 27-37 years). The mean ± SD age of postmenopausal reference women (52.16 ± 3.65 years) was higher than that of POI (46.28 ± 10.38 years) and premenopausal women (43.96 ± 7.08; P = 0.001) at the time of BMD measurement. Twenty-seven (84.4%) POI women were receiving hormone replacement therapy (HRT) at the time... Tipo: Info:eu-repo/semantics/article Palavras-chave: Premature ovarian failure; Premature menopause; Osteoporosis; Bone mineral density; Hypogonadism. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000100012 The FMR1 premutation as a cause of premature ovarian failure in Brazilian women Genet. Mol. Biol. Costa,Silvia S.; Fonseca,Angela M. da; Bagnoli,Vicente R.; Vianna-Morgante,Angela M.. The loss-of-function mutation of the FMR1 gene due to expansion of the 5' UTR CGG repeat causes the fragile X syndrome, the most frequent form of inherited mental retardation. On the other hand, the FMR1 premutation, which is transcriptionally active and produces the protein, confers an increased risk for premature ovarian failure (POF) to carrier females. Among 41 unrelated Brazilian women with idiopathic POF, we found three carriers of premutations (CGG expansionse > 59 repeats) and two carriers of high-intermediate alleles (50-55 repeats). Two premutations and two intermediate alleles were detected among the 16 familial POF cases, and one premutated woman, among the 25 sporadic cases. The premutation frequency among the familial cases (12.5%)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Premature ovarian failure; Menopause; FMR1 premutation; Fragile X syndrome. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000300002 Registros recuperados: 2 Primeira ... 1 ... Última

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