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| Zepeta-Flores,Nahum; Valverde,Mahara; Lopez-Saavedra,Alejandro; Rojas,Emilio. |
| Abstract The importance of glutathione (GSH) in alternative cellular roles to the canonically proposed, were analyzed in a model unable to synthesize GSH. Gene expression analysis shows that the regulation of the actin cytoskeleton pathway is strongly impacted by the absence of GSH. To test this hypothesis, we evaluate the effect of GSH depletion via buthionine sulfoximine (5 and 12.5 mM) in human neuroblastoma MSN cells. In the present study, 70% of GSH reduction did not induce reactive oxygen species, lipoperoxidation, or cytotoxicity, which enabled us to evaluate the effect of glutathione in the absence of oxidative stress. The cells with decreasing GSH levels acquired morphology changes that depended on the actin cytoskeleton and not on tubulin. We... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Glutathione; BSO; Thymosin β4; Gelsolin; Profiling. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000300475 |
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| Wong, Annie P. S.; Wijffels, Susan E.; Riser, Stephen C.; Pouliquen, Sylvie; Hosoda, Shigeki; Roemmich, Dean; Gilson, John; Johnson, Gregory C.; Martini, Kim; Murphy, David J.; Scanderbeg, Megan; Bhaskar, T. V. S. Udaya; Buck, Justin J. H.; Merceur, Frederic; Carval, Thierry; Maze, Guillaume; Cabanes, Cécile; André, Xavier; Poffa, Noe; Yashayaev, Igor; Barker, Paul M.; Guinehut, Stéphanie; Belbéoch, Mathieu; Ignaszewski, Mark; Baringer, Molly O'Neil; Schmid, Claudia; Lyman, John M.; Mctaggart, Kristene E.; Purkey, Sarah G.; Zilberman, Nathalie; Alkire, Matthew B.; Swift, Dana; Owens, W. Brechner; Jayne, Steven R.; Hersh, Cora; Robbins, Pelle; West-mack, Deb; Bahr, Frank; Yoshida, Sachiko; Sutton, Philip J. H.; Cancouët, Romain; Coatanoan, Christine; Dobbler, Delphine; Juan, Andrea Garcia; Gourrion, Jerome; Kolodziejczyk, Nicolas; Bernard, Vincent; Bourlès, Bernard; Claustre, Hervé; D'Ortenzio, Fabrizio; Le Reste, Serge; Le Traon, Pierre-yves; Rannou, Jean Philippe; Saout-grit, Carole; Speich, Sabrina; Thierry, Virginie; Verbrugge, Nathalie; Angel-benavides, Ingrid M.; Klein, Birgit; Notarstefano, Giulio; Poulain, Pierre-marie; Vélez-belchí, Pedro; Suga, Toshio; Ando, Kentaro; Iwasaska, Naoto; Kobayashi, Taiyo; Masuda, Shuhei; Oka, Eitarou; Sato, Kanako; Nakamura, Tomoaki; Sato, Katsunari; Takatsuki, Yasushi; Yoshida, Takashi; Cowley, Rebecca; Lovell, Jenny L.; Oke, Peter R.; Van Wijk, Esmee M.; Carse, Fiona; Donnelly, Matthew; Gould, W. John; Gowers, Katie; King, Brian A.; Loch, Stephen G.; Mowat, Mary; Turton, Jon; Rama Rao, E. Pattabhi; Ravichandran, M.; Freeland, Howard J.; Gaboury, Isabelle; Gilbert, Denis; Greenan, Blair J. W.; Ouellet, Mathieu; Ross, Tetjana; Tran, Anh; Dong, Mingmei; Liu, Zenghong; Xu, Jianping; Kang, Kiryong; Jo, Hyeongjun; Kim, Sung-dae; Park, Hyuk-min. |
| In the past two decades, the Argo Program has collected, processed, and distributed over two million vertical profiles of temperature and salinity from the upper two kilometers of the global ocean. A similar number of subsurface velocity observations near 1,000 dbar have also been collected. This paper recounts the history of the global Argo Program, from its aspiration arising out of the World Ocean Circulation Experiment, to the development and implementation of its instrumentation and telecommunication systems, and the various technical problems encountered. We describe the Argo data system and its quality control procedures, and the gradual changes in the vertical resolution and spatial coverage of Argo data from 1999 to 2019. The accuracies of the... |
| Tipo: Text |
Palavras-chave: Global; Ocean; Pressure; Temperature; Salinity; Argo; Profiling; Floats. |
| Ano: 2020 |
URL: https://archimer.ifremer.fr/doc/00652/76377/77385.pdf |
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