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Effect of Thyroxine and Propylthiouracil in Ehrlich Ascitic Tumor Cells International Journal of Morphology
Freitas,E. S.; Leite,E. D.; Silva,A. E.; Ocarino,N. M.; Ferreira,E.; Gomes,M. G.; Cassali,G. D.; Serakides,R.
The main purpose of this study was to investigate the effect of thyroxine and PTU in ascitic Ehrlich tumor cells. Tumor was implanted in 30 female mice distributed in three groups: treated with PTU, treated with thyroxine and control. Each group received an intraperitoneal injection of neoplastic cells, pre-incubated with sterile solutions of PTU, thyroxine and distilled water, respectively. On the fifth and seventh days after inoculation, animals received an intraperitoneal injection of the respective solutions. On the tenth day after inoculation, animals were sacrificed. Volume of ascitic liquid, number of neoplastic cells/ml and percentage of viable cells were determined. Ascitic liquid smears were carried out for tumor cytological evaluation. There was...
Tipo: Journal article Palavras-chave: Cytology; Ehrlich tumor; Mouse; NORs; Propylthiouracil; Thyroxine.
Ano: 2006 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000500024
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Effect of Transient Treatment with Propylthiouracil on Some Reproduction Traits and Live Weight of Japanese Quails Rev. Bras. Ciênc. Avic.
Sogut,B; Sengul,T; Inci,H; Sengul,Y; Ayasan,T.
ABSTRACT This study was conducted to investigate the effects of transient treatment with propylthiouracil (PTU) on some reproduction traits and live weight of quails. The trial lasted 8 weeks. To accomplish this goal, 700 1-day-old quail chicks were used, randomly divided into 8 groups. PTU was added to feed by 0.1% and 0.5% /wt. The first 4 groups had 0.5% PTU at the age of 2-4, 4-6, 6-8 and 2-8 wk., respectively. The 5 th, 6 th and 7 th groups had 0.1% PTU at the age of 2-4, 4-6 and 6-8 wk., respectively, and the 8 th group was the control with no PTU. Quails were bled at 60 days of age. Then right and left testes were taken out and weighed. At the end of the trail, least square means of the live weight of the treatment groups were higher than the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Quail; Propylthiouracil; Live weight; Reproduction traits.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2017000400711
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Model of induction of thyroid dysfunctions in adult female mice Arq. Bras. Med. Vet. Zootec.
Ferreira,E.; Silva,A.E.; Serakides,R.; Gomes,A.E.S.; Cassali,G.D..
It is described the elaboration of a protocol to induce hyperthyroidism and hypothyroidism in mice by administrating thyroxin and propylthiouracil, respectively, in the drinking water. The drugs were administered to adult female mice of the Swiss strain for 30 days in order to obtain a systemic status of thyroid dysfunction. The induction of hyperthyroidism and hypothyroidism in the animals was confirmed by the histomorphological analysis of the thyroid in the end of the experiment, when the state of gland dysfunction in the animals submitted to the treatment was observed.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mouse; Thyroid; Protocol; Induction; Thyroxin; Propylthiouracil.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352007000500022
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