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| Akl,Lívia D.; Valadares,Ana L.R.; Moraes,Monica Jacques de; Pinto-Neto,Aarão M.; Lagrutta,Bianca; Costa-Paiva,Lúcia. |
| ABSTRACT Objectives: To determine the prevalence of metabolic syndrome (MetS) and its associated factors in a group of HIV-infected middle-aged women. Methods: Cross-sectional study including 273 HIV-infected climacteric women of 40-60 years of age under care in two HIV outpatient reference centers in Brazil. Metabolic syndrome diagnosis was based on 2006 International Diabetes Federation criteria. Sociodemographic, clinical and behavioral factors were evaluated as well as HIV infection-related parameters. Results: Mean age was 47.7 years; 59.1% of women were premenopausal, 91% were on antiretroviral therapy. Current CD4 count was >500 cells/mm3 in 61.7%, current viral load undetectable in 76.9% of women, and a quarter had previous diagnosis of aids.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Metabolic syndrome; Menopause; HIV; Protease inhibitors. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300263 |
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| Tupinambás,Unaí; Aleixo,Agdemir; Greco,Dirceu. |
| Combined antiretroviral therapy results in sustained viral suppression and a decrease in mortality and morbidity due to HIV infection. Intrinsic strength, durability and absence of cross-resistance are key factors in the selection of antiretrovirals. Failure with nelfinavir has been associated with two protease gene mutations, D30N and L90M. The D30N mutation does not result in cross-resistance with other protease inhibitors, and it decreases viral fitness. In order to check for this mutation after failure with nelfinavir, the 246 HIV-1 genotyping test was performed on virus samples from 55 patients with failure of nelfinavir as the first protease inhibitor. Most (84%) of the viral strains were of subtype B. Nucleosides associated with mutations (NAM) were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV-1; Protease inhibitors; Nelfinavir. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400009 |
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| Tenore,S.B.; Ferreira,P.R.A.. |
| With the introduction of highly active antiretroviral therapy, a number of drugs have been developed. The best choice concerning which antiretroviral analogs to start is always under discussion, especially in the choice between non-nucleoside reverse transcriptase inhibitors-based therapies and ritonavir-boosted protease inhibitors. Both are proven to control viral replication and lead to immunological gain. The choice between a non-nucleoside analog reverse transcriptase inhibitor and a protease inhibitor as a third antiretroviral drug in the therapy should consider factors related to the individual, as well as the inclusion of the best therapy in the patient's daily activities and potential adherence. The protease inhibitor-based therapies showed similar... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: AIDS; Antiretroviral treatment; Protease inhibitors. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500012 |
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| Cavenaghi,F. M; Bataglion,C. A. N; Paula,P. C; Motta,A. C. F; Komesu,M. C. |
| Protease inhibitors (PIs), part of HAART (Highly Active Antiretroviral Therap) are selective, competitive inhibitors of protease, a crucial enzyme to viral maturation, infection and replication. A lipodystrophic syndrome has been reported in individuals treated with HAART, and associated to hyperglycemia, hypercholesterolemia, hypertrigliceridemia, hyperlipidemia, hypertension and hypreinsulinemia. The HAART-associated metabolic abnormalities were first associated with protease inhibitors, Ritonavir mostly, but the mechamisns that underlie these metabolic alterations are to date, not completely understood. Since PIs are candidate to be the drug of choice for other diseases treatment, such as the Hepatitis C, malaria and some types of cancer, it seems to be... |
| Tipo: Journal article |
Palavras-chave: Protease inhibitors; Dyslipidemia; Metabolic disorders. |
| Ano: 2012 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000200014 |
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| Martínez-Cárdenas,Leonardo; Frías-Quintana,Carlos A.; Álvarez-González,Carlos A.; Jiménez-Martínez,Luis D.; Martínez-García,Rafael; Hernández-Almeida,Oscar U.; Bello-Pineda,Javier; Arellano-Méndez,Leonardo U.; Ponce-Palafox,Jesús T.. |
| ABSTRACT Short-tailed pipe fish (Microphis brachyurus) is a freshwater organism with high economic potential for the aquarium hobby, so it is necessary to implement methods to promote its culture through studies of digestive physiology. General activities of acid and alkaline proteases were evaluated, as well as the effect of pH, temperature and inhibitors. The optimal pH of stomach proteases was 2, while the optimal pH of intestinal proteases was 10. Optimal temperature for the acidic proteases was 35 ºC, while for alkaline proteases it was 45 ºC. Thermal stability showed high resistance at 35 ºC for both acid and alkaline proteases (above 100% residual activity). Acid proteases are resistant at pH 2 (50% of residual activity), meanwhile alkaline... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Enzyme activity; Sygnathidae; PH; Protease inhibitors; Temperature. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-62252020000200212 |
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| Serquiz,Alexandre Coelho; Serquiz,Raphael Paschoal; Peixoto,Thayane Kerbele Oliveira das Neves; Santos,Elizeu Antunes dos; Rocha,Hugo Alexandre Oliveira. |
| ABSTRACT The benefits of various foods, such as fruits and vegetables, have been the focus of several studies aimed at improving welfare, health, and reducing the incidence of diseases. Therefore, the present paper objectified to investigate the presence of molecules of biotechnological and pharmacological interest in peel, seed, and pulp of Annona x atemoya Mabb. Aqueous extracts of the fruit parts were obtained with different buffers and assessed as to their protein and phenolic compounds content. The three parts of the fruit presented different proportions of these compounds when subject to different extraction conditions, with the highest concentrations of proteins being found in the seed and phenolic compounds in the peel of the studied fruit.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Annona x atemoya; Residues; Protease inhibitors; Lectins. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-29452018000100101 |
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