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| WISER,MARK F. |
| The export and trafficking of parasite proteins within the infected erythrocyte is a complex process and not well understood. Export of proteins from the parasite was previously speculated to involve a specialized compartment originally designated as the secondary endoplasmic reticulum of the Apicomplexa, or sERA. The properties of this Plasmodium export compartment are reviewed in regards to more recent observations about the trafficking of Plasmodium proteins within the host erythrocyte. In addition, a calcium ATPase unique to the Apicomplexa and with homology to the sarcoplasmicendoplasmic reticulum calcium ATPase is discussed in the context of this unique export compartment. It is also speculated that the Plasmodium export element, PEXEL, may play a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Secretory pathway; SERCA; Protein trafficking; Malaria. |
| Ano: 2007 |
URL: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-548X2007000200001 |
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| Ramírez,Omar A; Härtel,Steffen; Couve,Andrés. |
| Neurons are highly polarized, but the trafficking mechanisms that operate in these cells and the topological organization of their secretory organelles are still poorly understood. Particularly incipient is our knowledge of the role of the neuronal endoplasmic reticulum. Here we review the current understanding of the endoplasmic reticulum in neurons, its structure, composition, dendritic distribution and dynamics. We also focus on the trafficking of proteins through the dendritic endoplasmic reticulum, emphasizing the relevance of transport, retention, assembly of multi-subunit protein complexes and export. We additionally discuss the roles of the dendritic endoplasmic reticulum in synaptic plasticity. |
| Tipo: Journal article |
Palavras-chave: Endoplasmic reticulum; Protein trafficking; Dendrites; Neuron. |
| Ano: 2011 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000100003 |
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