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	Provedor de dados BJMBR (1) BJM (1) J. Venom. Anim. Toxins incl. Trop. Dis. (1) Autor Almeida,P.C. (1) Alves Junior,Nelson (1) Chagas,J.R. (1) Chérifi,Fatah (1) Coelho,Rosalie Reed Rodrigues (1) Laraba-Djebari,Fatima (1) Nascimento,Rodrigo Pires do (1) Pimenta,D.C. (1) Tersariol,I.L.S. (1) Mais... Palavra-chave Proteinases (3) Blood-clotting (1) Brewer's spent grains (1) Cerastes cerastes venom (1) Corn steep liquor (1) Glycosaminoglycan (1) Hemostasis (1) Heparin binding (1) Macromolecules (1) Phospholipases A2 (1) Platelets (1) Streptomyces malaysiensis (1) Submerged fermentation (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2013 (1) 2011 (1) 2002 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Isolated biomolecules of pharmacological interest in hemostasis from Cerastes cerastes venom J. Venom. Anim. Toxins incl. Trop. Dis. Chérifi,Fatah; Laraba-Djebari,Fatima. Biomolecules from Cerastes cerastes venom have been purified and characterized. Two phospholipases isolated from Cerastes cerastes venom share 51% of homology. CC2-PLA2 exhibits antiplatelet activity that blocks coagulation. CCSV-MPase, a non-hemorrhagic Zn2+-metalloproteinase, significantly reduced the plasmatic fibrinogen level and hydrolyzes only its Bβ chain. Serine proteinases such as RP34, afaâcytin and CC3-SPase hydrolyze the fibrinogen and are respectively α, αβ and αβ fibrinogenases. In deficient human plasma, afaâcytin replaces the missing factors VIII and IX, and activates purified human factor X into factor Xa. It releases serotonin from platelets and directly aggregates human (but not rabbit) blood platelets. RP34 proteinase also had no effect... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cerastes cerastes venom; Proteinases; Phospholipases A2; Platelets; Blood-clotting; Hemostasis. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100201 Proteinase activity regulation by glycosaminoglycans BJMBR Tersariol,I.L.S.; Pimenta,D.C.; Chagas,J.R.; Almeida,P.C.. There are few reports concerning the biological role and the mechanisms of interaction between proteinases and carbohydrates other than those involved in clotting. It has been shown that the interplay of enzymes and glycosaminoglycans is able to modulate the activity of different proteases and also to affect their structures. From the large number of proteases belonging to the well-known protease families and also the variety of carbohydrates described as widely distributed, only few events have been analyzed more deeply. The term "family" is used to describe a group of proteases in which every member shows an evolutionary relationship to at least one other protease. This relationship may be evident throughout the entire sequence, or at least in that part... Tipo: Info:eu-repo/semantics/article Palavras-chave: Proteinases; Heparin binding; Glycosaminoglycan; Macromolecules. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000200001 Brewer's spent grain and corn steep liquor as alternative culture medium substrates for proteinase production by Streptomyces malaysiensis AMT-3 BJM Nascimento,Rodrigo Pires do; Alves Junior,Nelson; Coelho,Rosalie Reed Rodrigues. Brewer's spent grain and corn steep liquor or yeast extract were used as the sole organic forms for proteinase production by Streptomyces malaysiensis in submerged fermentation. The influence of the C and N concentrations, as well as the incubation periods, were assessed. Eight proteolytic bands were detected through gelatin-gel-electrophoresis in the various extracts obtained from the different media and after different incubation periods, with apparent molecular masses of 20, 35, 43, 50, 70, 100, 116 and 212 kDa. The results obtained suggest an opportunity for exploring this alternative strategy for proteinases production by actinomycetes, using BSG and CSL as economically feasible substrates. Tipo: Info:eu-repo/semantics/article Palavras-chave: Streptomyces malaysiensis; Brewer's spent grains; Corn steep liquor; Proteinases; Submerged fermentation. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822011000400020 Registros recuperados: 3 Primeira ... 1 ... Última

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