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	Provedor de dados BJMBR (2) Autor Castellano,G. (2) Cendes,F. (1) Covolan,R.J.M. (1) Cuellar-Baena,S. (1) Dias,C.S.B. (1) Faria,A.V. (1) Foerster,B. (1) Li,L.M. (1) Morais,L.M.T.S. (1) Mais... Palavra-chave Proton magnetic resonance spectroscopy (2) AMARES (1) Brain activation (1) Brain energy metabolism (1) Brain tumors (1) Functional experiments (1) N-acetyl-L-aspartate (1) N-acetyl-aspartyl-glutamate (1) Tumor classification (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2012 (1) 2011 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Manual and semi-automatic quantification of in vivo ¹H-MRS data for the classification of human primary brain tumors BJMBR Cuellar-Baena,S.; Morais,L.M.T.S.; Cendes,F.; Faria,A.V.; Castellano,G.. In vivo proton magnetic resonance spectroscopy (¹H-MRS) is a technique capable of assessing biochemical content and pathways in normal and pathological tissue. In the brain, ¹H-MRS complements the information given by magnetic resonance images. The main goal of the present study was to assess the accuracy of ¹H-MRS for the classification of brain tumors in a pilot study comparing results obtained by manual and semi-automatic quantification of metabolites. In vivo single-voxel ¹H-MRS was performed in 24 control subjects and 26 patients with brain neoplasms that included meningiomas, high-grade neuroglial tumors and pilocytic astrocytomas. Seven metabolite groups (lactate, lipids, N-acetyl-aspartate, glutamate and glutamine group, total creatine, total... Tipo: Info:eu-repo/semantics/article Palavras-chave: Proton magnetic resonance spectroscopy; Brain tumors; AMARES; Tumor classification. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000400012 NAA and NAAG variation in neuronal activation during visual stimulation BJMBR Castellano,G.; Dias,C.S.B.; Foerster,B.; Li,L.M.; Covolan,R.J.M.. N-acetyl-aspartyl-glutamate (NAAG) and its hydrolysis product N-acetyl-L-aspartate (NAA) are among the most important brain metabolites. NAA is a marker of neuron integrity and viability, while NAAG modulates glutamate release and may have a role in neuroprotection and synaptic plasticity. Investigating on a quantitative basis the role of these metabolites in brain metabolism in vivo by magnetic resonance spectroscopy (MRS) is a major challenge since the main signals of NAA and NAAG largely overlap. This is a preliminary study in which we evaluated NAA and NAAG changes during a visual stimulation experiment using functional MRS. The paradigm used consisted of a rest period (5 min and 20 s), followed by a stimulation period (10 min and 40 s) and another... Tipo: Info:eu-repo/semantics/article Palavras-chave: Proton magnetic resonance spectroscopy; Functional experiments; Brain activation; Brain energy metabolism; N-acetyl-L-aspartate; N-acetyl-aspartyl-glutamate. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001100006 Registros recuperados: 2 Primeira ... 1 ... Última

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