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Evolution of HTLV-1 proviral load in patients from Salvador, Brazil BJID
Olavarria,Viviana Nilla; Gomes,Alline do Nascimento; Kruschewsky,Ramon de Almeida; Galvão-Castro,Bernardo; Grassi,Maria Fernanda Rios.
INTRODUCTION: Variations in human T cell lymphotropic virus type 1 (HTLV-1) proviral load (PVL) in infected individuals over time are not well understood. Objective: To evaluate the evolution of proviral load in asymptomatic individuals and HAM/TSP patients in order to help determine periodicity for measuring proviral load. METHODS: A group of 104 HTLV-1 infected patients, followed at the HTLV reference center in Salvador, Brazil, were included in the study (70 asymptomatic and 34 HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients). HTLV-1 PVL was measured using real-time polymerase chain reaction (PCR) at baseline and again at another point, either < 12 months, between 12-24 months, or &gt; 24 months. RESULTS: HAM/TSP...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asymptomatic; Evolution; HTLV-1; Proviral load; HAM/TSP.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400008
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Evaluation of the cervicovaginal environment in asymptomatic Human T-cell lymphotropic virus type 1 infected women BJID
Firmino,Alisson de Aquino; Martins,Adenilda Lima Lopes; Gois,Luana Leandro; Paixão,Taiane Silva; Batista,Everton da Silva; Galvão-Castro,Bernardo; Grassi,Maria Fernanda Rios.
ABSTRACT Introduction: Human T-cell lymphotropic virus type 1 (HTLV-1) is sexually transmitted and causes persistent infection. This virus induces activation of the immune system and production of inflammatory cytokines. This study aimed to assess the cytokine profile and cytopathological findings in the cervicovaginal fluid of asymptomatic HTLV-1-infected women. Methods: HTLV-1-infected and uninfected women were selected at the Centro de Atendimento ao Portador de HTLV in Salvador-Brazil. None of the included HTLV-1-infected women reported any HTLV-1-associated diseases. All volunteers underwent gynecological examination to collect cervicovaginal fluid. Cytokine quantification was performed using the Cytometric Bead Array (CBA) Human Th1/Th2/Th17 kit....
Tipo: Info:eu-repo/semantics/article Palavras-chave: HTLV-1; Inflammatory cytokines; Proviral load; Cervicovaginal cytopathology.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000100027
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