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Effects of purine nucleotide administration on purine nucleotide metabolism in brains of heroin-dependent rats BJPS
Li,Kun; Zhang,Ping; Chen,Li; Guan,Fengying.
ABSTRACT Heroin is known to enhance catabolism and inhibit anabolism of purine nucleotides, leading to purine nucleotide deficiencies in rat brains. Here, we determined the effect of exogenous purine nucleotide administration on purine nucleotide metabolism in the brains of heroin-dependent rats. Heroin was administrated in increasing doses for 9 consecutive days to induce addiction, and the biochemical changes associated with heroin and purine nucleotide administration were compared among the treated groups. HPLC was performed to detect the absolute concentrations of purine nucleotides in the rat brain cortices. The enzymatic activities of adenosine deaminase (ADA) and xanthine oxidase (XO) in the treated rat cortices were analyzed, and qRT-PCR was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Purine nucleotide/quantitative analysis; Purine nucleotide/effects/brain rats; Heroin analysis; Adenosine deaminase analysis; Xanthine oxidase analysis.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400787
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