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Liquid Chromatography Coupled to High-Resolution Mass Spectrometry for the Confirmation of Caribbean Ciguatoxin-1 as the Main Toxin Responsible for Ciguatera Poisoning Caused by Fish from European Atlantic Coasts ArchiMer
Estevez, Pablo; Sibat, Manoella; Leão-martins, José Manuel; Reis Costa, Pedro; Gago-martínez, Ana; Hess, Philipp.
Ciguatera poisoning (CP) is a common seafood intoxication mainly caused by the consumption of fish contaminated by ciguatoxins. Recent studies showed that Caribbean ciguatoxin-1 (C-CTX1) is the main toxin causing CP through fish caught in the Northeast Atlantic, e.g., Canary Islands (Spain) and Madeira (Portugal). The use of liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) combined with neuroblastoma cell assay (N2a) allowed the initial confirmation of the presence of C-CTX1 in contaminated fish samples from the abovementioned areas, nevertheless the lack of commercially available reference materials for these particular ciguatoxin (CTX) analogues has been a major limitation to progress research. The EuroCigua project allowed the...
Tipo: Text Palavras-chave: Ciguatoxins; HRMS; Q-TOF; Ciguatera poisoning; C-CTX1; Fragmentation pathways.
Ano: 2020 URL: https://archimer.ifremer.fr/doc/00624/73630/73067.pdf
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