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| Nascimento,Michele Cardoso do; Abreu,Clarice Lima do Canto; Costa,Rodrigo Netto; Delgado,Wlamir Correa de Moura; Fernandes,Isabella. |
| In this study, we compared the results of potency determination of recombinant human erythropoietin (rhEPO) obtained between 2010 and 2012 by the National Institute of Quality Control in Health (INCQS/Fiocruz), i.e., the National Control Laboratory (NCL), and by a manufacturer of rhEPO. In total, 47 different batches of commercially prepared rhEPO (alpha isoform) were analyzed. All results, including those of the control and warning limits, remained within the limits recommended by European Pharmacopoeia (Ph. Eur.). All relative error (RE) values were less than ± 30%, wh ereas most were approximately ± 20%. Applying the Bland-Altman plot, only two of 47 values remained outside the limits of agreement (LA). In addition, agreement of potency determination... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Recombinant Human Erythropoietin; Biological; Quality Control; Sanitary Surveillance. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000400562 |
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| Feucher, Charlene; Maze, Guillaume; Mercier, Herle. |
| In the north Atlantic subtropical gyre, the oceanic vertical structure of density is characterized by a region of rapid increase with depth. This layer is called the permanent pycnocline because this density feature is observed throughout the year. The pycnocline is the transition layer between light, low-latitude, surface water masses which are ventilated every winter when penetrated locally by the mixed layer and dense, deeper water masses whose properties are set in the high latitudes and circulate equatorward. In-situ data from the Argo array provide temperature/salinity profiles allowing the characterization in space and time of the permanent pycnocline. We thus developed a new method to characterize its depth, thickness and thermohaline... |
| Tipo: Text |
Palavras-chave: Argo; Quality Control; Pattern; Clustering; North Atlantic; Subtropical gyre; Stratification. |
| Ano: 2014 |
URL: http://archimer.ifremer.fr/doc/00242/35315/33838.pdf |
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