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| Registros recuperados: 128 | |
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| Pachioni,Célia Aparecida Stellutti; Mazzer,Nilton; Barbieri,Claudio Henrique; de Camargo,Marcela Regina; Fregonesi,Cristina Elena Prado Teles; do Carmo,Edna Maria; Nozabielli,Andrea Jeanne Lourenço; Martinelli,Alessandra Rezende. |
| The study aimed to verify the physiological injury behavior by stretching the soleus muscle of rats, using a noninvasive experimental model. Twenty-four rats were used and divided into three groups of eight animals: control group (A), group that performed tetanus followed by electrical stimulation and a sudden dorsiflexion of the left paw performed by a device equipped with a mechanism of muscle soleus rapid stretching (B); and a group that only received the tetanus (C). Three days later, the animals were killed, and the soleus muscle was resected and divided into three segments. Morphological changes indicative of muscle damage appeared in all three segments of group B. In a lesser degree, similar changes were also detected in muscles subjected to only... |
| Tipo: Journal article |
Palavras-chave: Disease models; Animal; Rats; Skeletal muscle; Tetany. |
| Ano: 2009 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400029 |
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| Gharbaran,Rajendra. |
| Metformin, an oral biguanide approved for the treatment of type II diabetes is widely prescribed for other clinical conditions. Currently, metformin is being investigated as potential anti-tumor agent. However, there have been recent concerns about hepatotoxicity associated with the use of metformin. This study, by means of high resolution transmission electron microscopy (TEM) and morphometry, investigated potential ultrastructural changes induced by metformin treatment on the hepatocytes of spontaneously hypertensive rats (SHR). Morphometric analysis was carried out on images of randomly selected cells from sectioned gluteraldehyde-osmium-fixed, Epon embedded liver tissue. One-way analysis of variance (ANOVA) on morphometric data showed statistically... |
| Tipo: Journal article |
Palavras-chave: Metformin; Rats; TEM; Cancer; Diabetes. |
| Ano: 2014 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300016 |
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| Sitthichai,Iamsaard; Wannisa,Sukhorum; Apichakarn,Sampannang; Bungorn,Sripanidkulchai. |
| Valproic acid (VPA), an anti-epileptic drug, has been reported to cause male sub/infertility. Together with searching for alternative treatments, the degrees to which testosterone levels and sperm quality are decreased under VPA treatment also need to be clarified. This study aimed to investigate the protective effects of Momordica cochinchinensis (MC) aril extract containing antioxidant capacity on adverse reproductive parameters induced with VPA. Rats were divided into 6 groups (control, VPA, 200 mg kg-1 of MC only, 50, 100, 200 mg kg-1 MC+VPA, respectively, n=8 in each). Animals were pretreated with MC extract for 23 days before co-administration with VPA (500 mg kg-1, i.p.) for 10 consecutive days. All reproductive parameters including histology, and... |
| Tipo: Journal article |
Palavras-chave: Androgen receptor (AR); Ki-67; Momordica cochinchinensis; Rats; Steroidogenic acute regulatory protein (StAR); Tyrosine testicular phosphorylated protein; Valproic acid. |
| Ano: 2017 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000300030 |
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| Lerma-Cabrera,Jose Manuel; Carvajal,Francisca; Alcaraz-Iborra,Manuel; Sanchez-Amate,Maria del Carmen; de la Fuente,Leticia; Cubero,Inmaculada. |
| Binge alcohol drinking during adolescence has been associated with neurotoxicity and increased risk for the development of alcohol use disorders. There is evidence that acute and chronic ethanol administration alters c-fos expression, an indirect index of cellular activity, in different brain regions in adult rats. We evaluate here if a binge-like pattern of ethanol exposure during adolescence has a relevant impact on basal and/or ethanol-stimulated regional c-fos activity during adulthood. For that aim, Sprague-Dawley rats PND 25 were saline pre-treated, (SP group) or binge-ethanol pre-treated (BEP group) for twoconsecutive days, at 48-h intervals, over a 14-day period (PND 25 to PND 38). At adult stage (PND 63) and following 25 ethanol-free days, we... |
| Tipo: Journal article |
Palavras-chave: -Fos; Immunoreactivity; Rats; Binge-like ethanol administration; Adolescent; Arcuate nucleus of hypothalamus (Arc); Central nucleus of the amygdala (CeA); Paraventricular nucleus of the hypothalamus (PVN). |
| Ano: 2014 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000200033 |
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| Vilaça Júnior,Paulo Estevao Araújo; Teixeira,Alvaro Aguiar Coelho; Wanderley Teixeira,Valéria; Moraes,Eleonora de Figueiredo; Araújo,Ana Claudia Carvalho de; Maia,Carina Scanoni. |
| The glucocorticoid dexamethasone has been largely used due to its anti-inflammatory effect. However, several authors report that the excessive exposition to it during pregnancy may cause a retard in the development in several tissues, mainly: liver, lungs and kidneys. But, the majority of the works are done with the application of dexamethasone in the late periods of pregnancy. Because of the lack of researches that evalúate the effects in the beginning of gestation, this paper aimed at evaluating the effect of dexamethasone administered in the initial phase of pregnancy, o ver the morphology of neonates rat. It was used 10 albino rats (Rattus norvegicus albinus) aged 90 days from the lineage Wistar. The female were coupled and divided in two groups: Group... |
| Tipo: Journal article |
Palavras-chave: Pregnancy; Dexamethasone; Histology; Rats. |
| Ano: 2008 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000300002 |
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| Iamsaard,Sitthichai; Arun,Supatcharee; Burawat,Jaturon; Sukhorum,Wannisa; Boonruangsri,Porntip; Namking,Malivalaya; Uabundit,Nongnut; Nualkaew,Somsak; Sripanidkulchai,Bungorn. |
| Valproic acid (VPA), widely used in treating epileptic patients, can damage reproductive parameters causing male infertility. This study aimed to investigate protective effect of Phyllanthus emblica L. branch (PE) extract on rat testicular damage induced with VPA. Male rats were divided into 6 groups (control, VPA, 250 mg/kgBW PE only, and 50, 100, 250 mg/kgBW PE+VPA, respectively). Animals were pretreated with PE for 23 days and co-administered with VPA for 10 days before all reproductive parameters were determined. The results showed all doses of PE significantly protected the decrease testicular weight and testosterone level in VPA rats. PE significantly improved the decrease sperm concentration in VPA treated rats. Moreover, testicular histology of... |
| Tipo: Journal article |
Palavras-chave: Valproic acid; Phyllanthus emblica L; Testicular damage; Rats. |
| Ano: 2015 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000300033 |
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| Pereira,Marli Aparecida dos Santos; Arantes,Márcia Alessandra; Molinari,Sonia Lucy; Zanoni,Jacqueline Nelisis; Miranda-Neto,Marcílio Hubner de. |
| The objective of our work was to verify, during an experimental period of 210 days, the possible effects of the ethanol on the morphology and density of the NADH-diaforase myenteric neurons in the jejunum of alcoholic rats. We used 10 animals (Rattus norvegicus) separated in 2 groups: the controls (n=5), that received a normal proteic diet (22%) and water ad libitum; the alcoholic, that received NUVILAB normal proteic chow (22%) and sugar cane brandy diluted at 30 Gay Lussac (30 v/v). The jejunum segment was collected and submitted to the histochemical technique to stain the nervous cells and, then, to the elaboration of membrane whole mounts. The observation through light microscopy showed that there are no expressive morphologic differences between the... |
| Tipo: Journal article |
Palavras-chave: Jejunum; Myenteric neurons; Rats; Alcoholism. |
| Ano: 2006 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000400016 |
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| De Carvalho,C. A. M; Thomazini,J. A. |
| The rat is probably the most commonly used animal in scientific research. There are many benefits to its use such as: ability to work a large number of animals allowing greater statistical validity, the relatively short life cycles. However, the scant literature regarding the anatomy and morphology of these animals is also old and not very descriptive. The objective of this research is to study the macroscopic morphometric aspects of several parameters that have not been described yet regarding the heart of Wistar rats in different phases of their lives. Thirty-six adult male and female rats (Rattus norvegicus) weighting 150-770 g were randomly divided into 6 experimental groups. The heart was then carefully dissected and removed from the chest. After this... |
| Tipo: Journal article |
Palavras-chave: Weight; Measures; Heart; Rats. |
| Ano: 2014 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000200039 |
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| Fernandes,Rodrigo M. P.; Abreu,Antonio V.; Schanaider,Alberto; Soares Jr.,Edivaldo R.; Pejanha,Gustavo C.A.; Babinski,Marcio A.; Ramos,Cristiane F.. |
| The purpose of this study was to evaluate the effects of maternal protein and energy restriction during lactation on the body weight and tibiae dimensions of pups at aging. At parturition, Wistar rat dams were randomly assigned to the following groups: 1) control group (C) - free access to a standard laboratory diet containing 23% protein, 2) protein-energy restricted group (PR) - free access to an isoenergetic, protein-restricted diet containing 8% protein, and 3) energy-restricted group (ER) - fed restricted amounts of a standard laboratory diet. At weaning, all pups were separated of dams and received free access to a standard laboratory diet containing 23% protein until 180 days when the rats were anesthetized and sacrificed. The dimensions of excised... |
| Tipo: Journal article |
Palavras-chave: Growth and development; Morphometry; Rats; Tibia; Undernutrition. |
| Ano: 2007 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000300016 |
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| Mugnaini,María Teresa; Soñez,Carlos Alberto; Rolando,Alicia Nélida; Romanini,María Cristina; Bozzo,Aída Andrea; Pastorino,Isabel Cecilia; Gauna,Héctor Fernando; Paz,Dante Agustín. |
| Exposure to physical or psychological stress causes brain damage ranging from minimal behavioural alterations to different neurodegeneration degrees implying the overproduction of oxidative-nitrosative compounds, apoptosis and cell proliferation. In the present investigation, we have analysed the effect of the chronic stress by immobilisation applied to pregnant rats over the forebrain development of the embryos. The morphometric analyses showed an accelerated evagination of the telencephalic vesicles in 12 days old fetus from stressed mothers. The forebrain perimeter and the thickness showed significative differences in relation to age-matched controls. This stress effect seemed reversible during subsequent gestational stages. This is the first work... |
| Tipo: Journal article |
Palavras-chave: Telencephalic vesicle; Chronic stress; Morphometric analysis; Rats. |
| Ano: 2006 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000500001 |
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| Hongfu,Liu; Luping,Zhang; Shaojie,Chen; Zengxian,Wang; Fei,Huang; Dong,Wang. |
| This study aimed to observe the regularity of liver cell apoptosis and expression of apoptosis related gene Bcl-2 and Bax in the induced cancer, and explore the relationship between apoptosis and the development of liver cancer. In this study, 84 rats were used, 72 rats as experimental group induced by drinking water containing DEN, 12 rats as control group (CG). After laparotomy, the form, color, texture of the liver and metastatic tumor in both control and experimental groups were observed and recorded. The metastatic tumor and the liver tissue were sectioned and stained with hematoxylin-eosin staining to demonstrate the characteristic in morphological changes, the Hoechst 33342 fluorescent staining was applied to show and count the rate of apoptotic... |
| Tipo: Journal article |
Palavras-chave: Primary hepatic carcinoma; Apoptosis; Bcl-2; Bax; Rats. |
| Ano: 2012 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000400032 |
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| Sukhorum,Wannisa; Sampannang,Apichakarn; Sripanidkulchai,Bungorn; Iamsaard,Sitthichai. |
| This study aimed to investigate protective effect of Momordica cochinchinensis (MC) aril extract on adverse reproductive parameters of male rat induced with valproic acid (VPA) commonly used in treatment for antiepileptic diseases. Male Wistar rats were divided into 6 groups (control, VPA, 200 mg/kg BW of PE only, and 50, 100, 200 mg/kg BW MC+VPA, respectively). Animals were pretreated with aqueous MC extract for 23 days before co-administered with VPA induction for 10 days. At the end of experiment, all male reproductive parameters and testicular histology were examined. The results showed all doses of PE significantly protect the decrease the weights of epididymis and seminal vesicle but not of body and testicular weights. MC extract also increased sperm... |
| Tipo: Journal article |
Palavras-chave: Momordica cochinchinensis; Valproic acid; Male reproductive parameters; Testicular damage; Rats. |
| Ano: 2016 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000300009 |
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| Degani Junior,Hugo V. M; Nunes,Viviane A; Bezerra,Ewerton C; Ramos,Cristiane F; Rodrigues,Mauro R; Abidu-Figueiredo,Marcelo; Cardoso,Gilberto P; Babinski,Marcio A. |
| The aim of this study was to evaluate the effects of maternal protein and energy restriction during lactation on mandible dimensions of pups (female) at aging. At parturition, Wistar rat dams were randomly assigned to the following groups: 1) control group (C) - free access to a standard laboratory diet containing 23% protein, 2) protein-energy restricted group (PER) - free access to an isoenergetic, protein-restricted diet containing 8% protein, and 3) energy-restricted group (ER) fed with restricted amounts of a standard laboratory diet. At weaning (d21), all pups were separated of dams and received free access to a standard laboratory diet containing 23% protein until 90 days (d90), when the rats were anesthetized and sacrificed. The dimensions of... |
| Tipo: Journal article |
Palavras-chave: Growth and development; Morphometry; Rats; Mandible; Undernutrition. |
| Ano: 2011 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000200050 |
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| Moraes,Eleonora de Figueiredo; Wanderley Teixeira,Valéria; Teixeira,Álvaro Aguiar Coelho; Silva,Welma Emídio da; Batista,Ana Paula Castor; Lemos,Ana Janaína Jeanine Martins de. |
| The present study had the objective of obtaining information about fertility in rats treated with dexamethasone for 10 and 15 days consecutively, to polycystic ovaries, induced by constant illumination. It was used 40 albino rats (Rattus norvegicus albinus), aged 90 days, form the lineage Wistar, which were split, randomly, in four groups, each constituted of 10 animals, namely: Group I - rats kept in a clear/dark cycle for 12/12 hours, and after 100 days submitted to fertility evaluation (control); Group II - rats kept under constant illumination during 100 days and then submitted to fertility evaluation; Group III - rats kept under constant illumination during 100 days, then treated with dexamethasone for 10 days and submitted to fertility evaluation;... |
| Tipo: Journal article |
Palavras-chave: Fertility; Polycystic ovaries; Dexamethasone; Rats. |
| Ano: 2008 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000300024 |
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| Buljubacich,Karina Alejandra; Mugnaini,María Teresa; Soñez,Carlos Alberto; Rolando,Alicia Nélida; Romanini,María Cristina; Bozzo,Aída Andrea; Soñez,María Cristina; Gauna,Héctor Fernando. |
| The aim of this work was to determine the chronical stress effects on the encephalic NPY neurons population during the fetal Central nervous system development. Immunocytochemical techniques were used for this purpose: NPY neurons presented a similar morphology during the gestation days studied but their distribution varied in the anterior, medium and posterior brain. Statistical Highly significant differences in number of NPY positive neurons (p<0.01) among anterior, medium and posterior brain of stressed fetus (SF) were determined depending on the gestation period and the brain area. The NPY neurons were increased in ARC (Arcuate Hypothalamic Nucleus), PH (Posterior Hypothalamic Area) and DM (Dorsomedial Hypothalamic Nucleus) in stressed fetuses (SF)... |
| Tipo: Journal article |
Palavras-chave: NPY; Prenatal chronical stress; CNS; Rats. |
| Ano: 2009 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300039 |
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| Castoldi,Robson Chacon; Aleixo,Paulo Henrique; Pereira,Alysson Christian Jesus; Ferreira,Sergio Ruiz; Garcia,Thiago Alves; Ozaki,Guilherme Akio Tamura; Koike,Tatiana Emy; Júnior,Danilo Antônio Corrêa Pinto; Seraphim,Patrícia Monteiro; Belangero,William Dias; Filho,José Carlos Silva Camargo. |
| To analyze the effects of concurrent training (CT) on the muscle fibers of Wistar rats submitted to standard and hypercaloric diets. In total, 40 rats were used, divided into 4 groups: Sedentary Group (GS); Exercise Group (GE), Obese Sedentary Group (OS) and Obese Exercise Group (OE). The animals performed a CT protocol consisting of: muscle strength training and aerobic training, carried out 3 times a week for 45 days. The smallest diameter of muscle fibers (MDF) was analyzed to evaluate muscle hypertrophy. It was observed that the OE group presented a significant decrease in MDF, compared to the OS group (OE=77.41 µm vs. OS=98.58 µm). In addition, the animals that performed CT demonstrated muscle hypertrophy (GE=74.39 µm vs. GS=72.13 µm). In conclusion,... |
| Tipo: Journal article |
Palavras-chave: Training; Muscles; Hypertrophy; Rats; Obesity. |
| Ano: 2017 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200041 |
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| Ottone,Nicolás Ernesto; Cirigliano,Vanina; Lewicki,Marianela; Bianchi,Homero F; Aja-Guardiola,Santiago; Algieri,Rubén Daniel; Cantin,Mario; Fuentes,Ramón. |
| Today, alternatives methods are developed for the use of laboratory animals for teaching, research and surgical training. In our work we present a novel alternative to the use of rats, by developing a technique of plastination at room temperature. High-quality rat preparations from the anatomical dissection point of view were obtained, in order to indefinitely preserve them dry, the thoracic and abdominal organs conserve its natural volume and shape, maintaining their texture and color. No odors or hassles and toxic vapors of conventional preserving agents were found. This technique allows the collection of dry, completely biosafe and durable specimens in a short time and with excellent quality. Plastination in laboratory rats complements undergraduate and... |
| Tipo: Journal article |
Palavras-chave: Plastination; Room temperature; Laboratory animals; Rats. |
| Ano: 2014 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000400048 |
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| Registros recuperados: 128 | |
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