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Correlations of recognition memory performance with expression and methylation of brain-derived neurotrophic factor in rats Biol. Res.
Muñoz,Pablo C; Aspé,Mauricio A; Contreras,Luis S; Palacios,Adrián G.
Object recognition memory allows discrimination between novel and familiar objects. This kind of memory consists of two components: recollection, which depends on the hippocampus, and familiarity, which depends on the perirhinal cortex (Pcx). The importance of brain-derived neurotrophic factor (BDNF) for recognition memory has already been recognized. Recent evidence suggests that DNA methylation regulates the expression of BDNF and memory. Behavioral and molecular approaches were used to understand the potential contribution of DNA methylation to recognition memory. To that end, rats were tested for their ability to distinguish novel from familiar objects by using a spontaneous object recognition task. Furthermore, the level of DNA methylation was...
Tipo: Journal article Palavras-chave: DNA methylation; Recognition memory; Synaptic plasticity; Hippocampal; Perirhinal cortex; BDNF.
Ano: 2010 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000200013
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Effect of the time-of-day of training on explicit memory BJMBR
Barbosa,F.F.; Albuquerque,F.S..
Studies have shown a time-of-day of training effect on long-term explicit memory with a greater effect being shown in the afternoon than in the morning. However, these studies did not control the chronotype variable. Therefore, the purpose of this study was to assess if the time-of-day effect on explicit memory would continue if this variable were controlled, in addition to identifying the occurrence of a possible synchronic effect. A total of 68 undergraduates were classified as morning, intermediate, or afternoon types. The subjects listened to a list of 10 words during the training phase and immediately performed a recognition task, a procedure which they repeated twice. One week later, they underwent an unannounced recognition test. The target list and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Memory; Circadian rhythms; Explicit memory; Recognition memory.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000600007
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Behavioral deficits in sepsis-surviving rats induced by cecal ligation and perforation BJMBR
Barichello,T.; Martins,M.R.; Reinke,A.; Constantino,L.S.; Machado,R.A.; Valvassori,S.S.; Moreira,J.C.F.; Quevedo,J.; Dal-Pizzol,F..
Sepsis and its complications are the leading causes of mortality in intensive care units, accounting for 10-50% of deaths. Intensive care unit survivors present long-term cognitive impairment, including alterations in memory, attention, concentration, and/or global loss of cognitive function. In the present study, we investigated behavioral alterations in sepsis-surviving rats. One hundred and ten male Wistar rats (3-4 months, 250-300 g) were submitted to cecal ligation and puncture (CLP), and 44 were submitted to sham operation. Forty-four rats (40%) survived after CLP, and all sham-operated animals survived and were used as control. Twenty animals of each group were used in the object recognition task (10 in short-term memory and 10 in long-term memory),...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sepsis survivors; Recognition memory; Plus-maze test; Forced swimming test; Cecal ligation and puncture; Cognitive impairment.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000600013
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