|
|
|
|
|
| Cammarota,Martín; Barros,Daniela M.; Vianna,Mónica R.M.; Bevilaqua,Lia R.M.; Coitinho,Adriana; Szapiro,Germán; Izquierdo,Luciana A.; Medina,Jorge H.; Izquierdo,Iván. |
| Memory is measured by measuring retrieval. Retrieval is often triggered by the conditioned stimulus (CS); however, as known since Pavlov, presentation of the CS alone generates extinction. One-trial avoidance (IA) is a much used conditioned fear paradigm in which the CS is the safe part of a training apparatus, the unconditioned stimulus (US) is a footshock and the conditioned response is to stay in the safe area. In IA, retrieval is measured without the US, as latency to step-down from the safe area (i.e., a platform). Extinction is installed at the moment of the first unreinforced test session, as clearly shown by the fact that many drugs, including PKA, ERK and protein synthesis inhibitors as well as NMDA receptor antagonists, hinder extinction when... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Memory; Retrieval; Extinction; Reconsolidation; Inhibitory avoidance. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000300011 |
| |
|
| |
|
|
| Baratti,C.M.; Boccia,M.M.; Blake,M.G.. |
| In this article, we will review some behavioral, pharmacological and neurochemical studies from our laboratory on mice, which might contribute to our understanding of the complex processes of memory consolidation and reconsolidation. We discuss the post-training (memory consolidation) and post-reactivation (memory reconsolidation) effects of icv infusions of hemicholinium, a central inhibitor of acetylcholine synthesis, of intraperitoneal administration of L-NAME, a non-specific inhibitor of nitric oxide synthase, of intrahippocampal injections of an inhibitor of the transcription factor NF-κB, and the exposure of mice to a new learning situation on retention performance of an inhibitory avoidance response. All treatments impair long-term memory... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Memory; Consolidation; Reconsolidation; Extinction; Inhibitory avoidance. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000200001 |
| |
|
|
|
