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Registros recuperados: 25 | |
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Gras, S; Chaumont, V; Fernandez, B; Carpentier, P; Charrier Savournin, F; Schmitt, Sophie; Pineau, C; Flament, Didier; Hecker, A; Forterre, P; Armengaud, J; Housset, D. |
The human XAB1/ MBDin GTPase and its close homologues form one of the ten phylogenetically distinct families of the SIMIBI ( after signal recognition particle, MinD and BioD) class of phosphate- binding loop NTPases. The genomic context and the partners identified for the archaeal and eukaryotic homologues indicate that they are involved in genome maintenance - DNA repair or replication. The crystal structure of PAB0955 from Pyrococcus abyssi shows that, unlike other SIMIBI class G proteins, these highly conserved GTPases are homodimeric, regardless of the presence of nucleotides. The nucleotide- binding site of PAB0955 is rather rigid and its conformation is closest to that of the activated SRP G domain. One insertion to the G domain bears a strictly... |
Tipo: Text |
Palavras-chave: Structure; SIMIBI; Replication; GTPase; Crystal. |
Ano: 2007 |
URL: http://archimer.ifremer.fr/doc/2007/publication-4724.pdf |
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Okubo, Kazuhiro; Yokoyama, Naoaki; Govind, Yadav; Alhassan, Andy; Igarashi, Ikuo. |
In the present study, we examined the effects of four kinds of cysteine protease inhibitors (E64, E64d, leupeptin, and ALLN) on the in vitro asexual growth of Babesia bovis. Of these, only the lipophilic inhibitors, E64d and ALLN, were found to effectively inhibit the growth of B. bovis. In further experiments, E64d, but not ALLN, significantly suppressed the parasite’s invasion of host erythrocytes, while both chemicals, especially ALLN, inhibited the parasite’s replication within the infected erythrocytes. These data suggested the presence of cysteine protease(s) derived from B. bovis, in which the protease(s) would play important roles in the erythrocyte invasion and/or replication processes of the parasite. |
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Palavras-chave: Babesia bovis; Cysteine protease; Inhibitor; Invasion; Replication. |
Ano: 2007 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/1041 |
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Registros recuperados: 25 | |
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