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| Wei,Hongwei; Chang,Jinhua; Liu,Pei; Li,Zhongsi; Miao,Guangxin; Liu,Xigang; Liu,Cuizhe; Zhang,Xiangrong. |
| Rhubarb is commonly used as a cathartic in Asian countries. However, researchers have devotedextensive concerns to the quality control and safety of rhubarb and traditional Chinese preparations composed of rhubarb due to the instable purgative effect and potential nephrotoxicity of anthraquinones. In this study, we aimed to prepare rhubarb total free anthraquinones (RTFA) oral colon-specific drug delivery granules (RTFA-OCDD-GN) to delivery anthraquinones to colon to produce purgative effect. RTFA-OCDD-GN were prepared using chitosan and Eudragit S100 through a double-layer coating process and the formulation was optimized. Continuous release studies were performed in a simulated gastric fluid (pH 1.2), followed by a small-intestinal fluid (pH 6.8) and a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rhubarb; Anthraquinones; Oral colon-specific drug delivery granules; Dissolution; Purgative activity. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100500 |
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