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Short-term oral administration of risperidone induces pancreatic damage and hyperamylasemia in Sprague-dawley rats BJPS
Shah,Rehmat; Subhan,Fazal; Sultan,Syed Muhammad; Ali,Gowhar.
Risperidone is an atypical antipsychotic acting mainly as a dopamine D2 and serotonin 5-HT2 receptors antagonist prescribed in the treatment of schizophrenia and various affective disorders. Risperidone has been reported to be associated with weight gain, panreatitis and type 2 diabetes mellitus. Various mechanisms of risperidone-induced toxicities have been reported but the histology of tissues especially pancreas has never been studied. Therefore, the current study was designed to elucidate the toxic effects of chronic administration of risperidone on pancreas, liver and kidneys. Animals (rats) of either gender were divided into two groups, the risperidone and control groups. Risperidone was administered in a dose of 2.5 mg/kg/d for three weeks. The...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Risperidone/antipsychotics/oral administration/effects; Histopathology; D2 antagonist; Pancreas.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400629
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